FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tsc1S533A.Tub
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General Information
Symbol
Dmel\Tsc1S533A.Tub
Species
D. melanogaster
Name
FlyBase ID
FBal0298044
Feature type
allele
Associated gene
Dmel\Tsc1
Associated Insertion(s)
Carried in Construct
P{Tub-Tsc1.S533A}
Key Links
Transgenic product class
missense_variant
(Schleich and Teleman, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schleich and Teleman, 2009)
Mutagen
in vitro construct
(Schleich and Teleman, 2009)
Progenitor genotype
Carried in construct
P{Tub-Tsc1.S533A}
Cytology
Description

A tubulin promoter drives expression of Tsc1 containing the amino acid replacement S533A.

(Schleich and Teleman, 2009)
Allele components
Component
Use(s)
Encoded product / tool
Tsc1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      PRAS40KO, Tsc1S533A.Tub, gig4A.αTub flies are viable and normal in size.

      (Pallares-Cartes et al., 2012)

      Tsc129 gig192 double mutants carrying both Tsc1S533A.Tub and gig4A.αTub are viable and normal in size, although they show a slight reduction in lipid levels compared to wild type.

      (Schleich and Teleman, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Tsc1S533A.Tub rescues Tsc129

      (Schleich and Teleman, 2009)
      Comments

      Tsc129 flies carrying Tsc1S533A.Tub are viable and normal in size.

      (Schleich and Teleman, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TSC1(A)
      (Pallares-Cartes et al., 2012)
      Tsc1S533A.Tub
      Tsc1S533A
      (Schleich and Teleman, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)