FlyBase Allele Report: Dmel\Pen[-UTR.UASp]

General Information

Symbol

Dmel\Pen^-UTR.UASp

Species

D. melanogaster

Name

FlyBase ID

FBal0176053

Feature type

allele

Associated gene

Dmel\Pen

Associated Insertion(s)

Carried in Construct

P{UASp-Pen.-UTR}

Key Links

Transgenic product class

wild_type

(Mason et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mason et al., 2003)

Mutagen

in vitro construct

(Mason et al., 2003)

Progenitor genotype

Carried in construct

P{UASp-Pen.-UTR}

Cytology

Description

UASp regulatory sequences drive expression of the Pen ORF (no UTRs).

(Mason et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Pen

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

majority die during embryonic stage | maternal effect, with Pen^D14, Scer\GAL4^{VP16.nanos.UTR}

(Virágh et al., 2012)

partially lethal - majority die | maternal effect, with Pen^D14, Scer\GAL4^{VP16.nanos.UTR}

(Virágh et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Pen^-UTR.UASp is a suppressor | partially of increased mortality during development | maternal effect phenotype of Fs(2)Ket^RE34, Pen^D14

(Virágh et al., 2012)

Pen^-UTR.UASp/Scer\GAL4^αTub84B.PL is a suppressor | partially of lethal | larval stage phenotype of Kap-α3^17-7/Kap-α3^D93

(Mason et al., 2003)

Scer\GAL4^Act5C.PI/Pen^-UTR.UASp is a suppressor | partially of lethal | larval stage phenotype of Kap-α3^17-7/Kap-α3^D93

(Mason et al., 2003)

Pen^-UTR.UASp/Scer\GAL4^αTub84B.PL is a suppressor of lethal | larval stage phenotype of Kap-α3^D93

(Mason et al., 2003)

Scer\GAL4^Act5C.PI/Pen^-UTR.UASp is a suppressor of lethal | larval stage phenotype of Kap-α3^D93

(Mason et al., 2003)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Pen^-UTR.UASp/Scer\GAL4^ey.PH is a non-suppressor of eye | somatic clone phenotype of Kap-α3^D93

(Mason et al., 2003)

Pen^-UTR.UASp/Scer\GAL4^ey.PH is a non-suppressor of ommatidium | somatic clone phenotype of Kap-α3^D93

(Mason et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pen^{-UTR.Scer\UAS.P\T} under the control of Scer\GAL4^Act5C.PI does not restore fertility in Df(3L)α1S1 males.

Expression of Pen^{-UTR.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} does not restore fertility or fecundity in Df(3L)α1S1 females.

(Ratan et al., 2008)

Pen^{-UTR.Scer\UAS.P\T} driven by Scer\GAL4^Act5C.PI or Scer\GAL4^αTub84B.PL can weakly suppress the first instar larval lethality of Kap-α3^D93 homozygotes or Kap-α3^D93/Kap-α3^17-7 animals. Many larvae survive to second or early third instar, and occasionally animals survive to pupation (or even pharate adult stage in the case of the heterozygotes). Pen^{-UTR.Scer\UAS.P\T}; Scer\GAL4^ey.PH fails to suppress the eye phenotypes due to Kap-α3^D93 somatic clones.

(Mason et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pen^{-UTR.Scer\UAS.P\T}

Pen^-UTR.UASp

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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