FlyBase Allele Report: Dmel\Ada2b[2]

General Information

Symbol

Dmel\Ada2b²

Species

D. melanogaster

Name

FlyBase ID

FBal0176419

Feature type

allele

Associated gene

Dmel\Ada2b

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Qi et al., 2004)

Progenitor genotype

P{EP}EP3412

(Qi et al., 2004)

Cytology

Description

Imprecise excision of the P{EP} element, resulting in a 2.77kb deletion that deletes almost the entire Ada2b gene.

(Qi et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:8,237,819..8,240,595 [-]

Comment:

Imprecise excision of the P{EP} element, resulting in a 2.77kb deletion that removes almost the entire Ada2b gene.

(Qi et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | germline clone | recessive

(Qi et al., 2004)

lethal - all die before end of pupal stage | recessive

(Qi et al., 2004)

some die during pupal stage | recessive

(Qi et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes die during early pupal stages, mostly before head eversion occurs, without any other gross morphological abnormalities. No eggs are obtained from females containing homozygous germline clones.

(Qi et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Ada2b² is a non-suppressor of increased cell death | heat sensitive phenotype of rpr^hs.PW

(Qi et al., 2004)

Other

Statement

Reference

Ada2b², p53^5A-1-4 has abnormal cell death | conditional phenotype

(Qi et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ada2b[+]/Ada2b² is an enhancer of wing margin phenotype of mam^g2.1

(Gause et al., 2006)

NOT Enhancer of

Statement

Reference

Ada2b[+]/Ada2b² is a non-enhancer of wing blade phenotype of N^nd-1

(Gause et al., 2006)

NOT Suppressor of

Statement

Reference

Ada2b[+]/Ada2b² is a non-suppressor of wing vein L4 phenotype of N^Ax-E2

(Gause et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Ada2b² increases the number of wing margin nicks seen in mam^g2.1 heterozygotes.

(Gause et al., 2006)

p53^5A-1-4 Ada2b² double mutant third instar wing discs show a small amount of apoptosis in the absence of irradiation, but there is no increase in apoptosis in these discs following irradiation.

(Qi et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ada2b² is rescued by Ada2b^+t6.1

(Qi et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ada2b²

(Gause et al., 2006)

dAda2b²

(Qi et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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