FlyBase Allele Report: Dmel\foxo[W24]

General Information

Symbol

Dmel\foxo^W24

Species

D. melanogaster

Name

FlyBase ID

FBal0179838

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

P{lacW}foxo^W24

Carried in Construct

Also Known As

dfoxo^w24, foxo²⁴

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Weber et al., 2005)

Progenitor genotype

Associated Insertion(s)

P{lacW}foxo^W24

Cytology

Description

P{lacW} insertion in the first intron, between the last two bases (A and G) of the intron.

(Weber et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Weber et al., 2005)

Phenotype Manifest In

wing

(Weber et al., 2005)

Detailed Description

Statement

Reference

30 day old flies show a significant reduction in the numbers of commensal bacteria in the gut compared to age-matched controls.

(Guo et al., 2014)

foxo^W24 animals show no obvious visible effect on the size, shape or venation of the wings. However, when wing shape metrics are analysed using angular offsets for four wing-shape indices, foxo^W24 animals do show small effects on wing shape compared to the control parent lines.

(Weber et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

foxo^W24/foxo[+] is a suppressor of abnormal starvation stress response | recessive | adult stage phenotype of Rel^E20

(Molaei et al., 2019)

Other

Statement

Reference

Rel^E20, foxo^W24/foxo[+] has viable phenotype

(Molaei et al., 2019)

Rel^E20, foxo^W24 has partially lethal - majority die | recessive phenotype

(Molaei et al., 2019)

Rel^E20, foxo^W24 has majority die during P-stage | recessive phenotype

(Molaei et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

foxo^W24/foxo[+] is a suppressor of adult fat body | nutrition conditional phenotype of Rel^E20

(Molaei et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

dFoxo^w24

(Kenmoku et al., 2017)

dfoxo^w24

(Kuo et al., 2012)

foxo²⁴

(Molaei et al., 2019, Chng et al., 2017)

foxo^W24

(Guo et al., 2014, Karpac et al., 2013, Becker et al., 2010)

foxo^w24

(Vandehoef et al., 2020, Molaei et al., 2019, Cognigni et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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