Scer\GAL4^Bx-MS1096-mediated expression of Gαo^GTP.Scer\UAS results in clearly visible defects in stout sensory bristle formation on the adult wing margin.

Approximately 50% of flies expressing constitutively active G-oα47A^GTP.Scer\UAS in LN[[v]] neurons under the control of Scer\GAL4^P0.5.Pdf are arrhythmic The remaining rhythmic flies have short period rhythms (22.3hr), although with a weak power.

The response of the ab1C neuron to CO[[2]] is unaffected in animals expressing G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^Gr21a.9.323.

The odour responses of the ab1A, ab2A and ab3A olfactory receptor neurons are unaffected in animals expressing G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^{Orco.T:Hsim\VP16}.

Expression of G-oα47A^GTP.Scer\UAS, under the control of Scer\GAL4^pnr-MD237 results in bristle orientation defects and bald regions of the thorax. Scer\GAL4^pnr-MD237 drives expression of G-oα47A^GTP.Scer\UAS in eight thoracic macrochaetae, and on average, 15% of these macrochaetae are lost per thorax, with all thoraces exhibiting loss of at least one macrochaeta. Defects, due to aberrations in asymmetric division, including the absence of external cells, duplicated sockets and/or hairs, and bristles devoid of sockets or hairs are observed in G-oα47A^GTP.Scer\UAS Scer\GAL4^pnr-MD237 mutants. Approximately 8% of G-oα47A^GTP.Scer\UAS Scer\GAL4^pnr-MD237 bristles exhibit hair/socket duplications. Socket-only phenotypes occur in 28% of cases. Flies expressing G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^pnr-MD237 exhibit defective wing margin stout bristles. Defective bristles exhibit a range of phenotypes, they may contain: two sockets/two hairs, one socket/three hairs, one socket/two hairs, two sockets/one hair, no socket/two hairs, no socket/one hair, or one or two sockets/no hair. Flies expressing G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 exhibit defects in approximately 3% of wing margin bristles. In flies expressing G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^sca-537.4, the internal cells of sensory organ precursors (SOPs) can duplicate at the expense of external cells, forming two neuronal and two sheath cells, in approximately 10% of bristles. In approximately 1% of cases, four neuronal cells are formed. This is consistent with the bald regions observed on the adult thorax in this genotype, resulting from pIIa-to-pIIb transformations. External cells can also be duplicated in this genotype. In approximately 4% of cases, the SOP cluster duplicates the socket cells at the expense of neuronal specification.

Expression of G-oα47A^GTP.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 induces multiple wing hairs. This phenotype is cell autonomous.

Expression of G-oα47A^GTP.Scer\UAS in glia of embryos, driven by Scer\GAL4^repo, causes defects in the formation of the blood-brain barrier, as assessed by the penetrance of a fluorescent dye into the nerve cord.

Gαo^GTP.UAS, Scer\GAL4^P0.5.Pdf has abnormal circadian rhythm phenotype, non-suppressible by Gnf1^GD4455, Scer\GAL4^P0.5.Pdf

Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096 has abnormal planar polarity phenotype, non-suppressible by fz^unspecified

Gαo^GTP.UAS, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^GMR.PU

Gαo^GTP.UAS, Scer\GAL4^P0.5.Pdf is a non-suppressor of abnormal circadian rhythm phenotype of Plc21C^GD11359, Scer\GAL4^P0.5.Pdf

Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096 has wing margin bristle phenotype, enhanceable by Dhit^KK109401, Scer\GAL4^Bx-MS1096

Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096 has wing margin bristle phenotype, enhanceable by Dhit^ex183/Dhit^ex274

Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096 has wing hair | increased number phenotype, non-suppressible by fz^unspecified

Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096 has wing hair phenotype, non-suppressible by fz^unspecified