FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cenp-CIR35
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General Information
Symbol
Dmel\Cenp-CIR35
Species
D. melanogaster
Name
FlyBase ID
FBal0190490
Feature type
allele
Associated gene
Dmel\Cenp-C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q858term.

    (Heeger et al., 2005)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:8,567,022..8,567,022 [+]
    Nucleotide change:

    C8567022T

    Amino acid change:

    Q858term | Cenp-C-PA; Q846term | Cenp-C-PB

    Reported amino acid change:

    Q858term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Heeger et al., 2005)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cenp-CZ3-4375/Cenp-CIR35 females show defects in centromere clustering in the oocyte, with a failure of clustering being evidence by pachytene in region 3 of the germarium (centromere clustering at the earlier zygotene stage is normal). Defects in centromere pairing are also seen.

        The centromeres are separated from the nucleolus in the oocytes of Cenp-CZ3-4375/Cenp-CIR35 females (in contrast to wild type where they are adjacent).

        Heterozygous females show significantly increased X chromosome nondisjunction compared to wild-type controls. The nondisjunction events occur in meiosis I.

        (Unhavaithaya and Orr-Weaver, 2013)

        Mutants show cell cycle defects during embryogenesis.

        (Heeger et al., 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        Cenp-CIR35 has abnormal meiotic cell cycle | semidominant phenotype, enhanceable by cal12k32/cal1[+]

        (Unhavaithaya and Orr-Weaver, 2013)
        Enhancer of
        Statement
        Reference

        Cenp-C[+]/Cenp-CIR35 is an enhancer of abnormal meiotic cell cycle | semidominant phenotype of cal12k32

        (Unhavaithaya and Orr-Weaver, 2013)

        Cenp-CIR35 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, pimUAS.Tag:MYC

        (Heeger et al., 2005)

        Cenp-C[+]/Cenp-CIR35 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, cidUAS.cJa

        (Heeger et al., 2005)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Cenp-CIR35/Df(3R)Exel6176 double heterozygous females do not show a significant increase in X chromosome non disjunction compared to wild-type controls.

        (Unhavaithaya and Orr-Weaver, 2013)

        cal12k32/Cenp-CIR35 and Df(3R)Exel6176/Cenp-CIR35 double heterozygous females show defects in centromere clustering in the oocyte, with defects being evident by region 3 of the germarium. Defects in centromere pairing are also seen.

        The centromeres are separated from the nucleolus in the oocytes of double heterozygous cal12k32/Cenp-CIR35 females (in contrast to wild type where they are adjacent).

        cal12k32/Cenp-CIR35 double heterozygous females show significantly increased X and 4th chromosome nondisjunction compared to wild-type controls, with the frequency of nondisjunction being increased compared to the phenotypes seen in single heterozygotes.

        (Unhavaithaya and Orr-Weaver, 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Cenp-CIR35/Cenp-CZ3-4375 is rescued by Cenp-CEYFP

        (Unhavaithaya and Orr-Weaver, 2013)
        Comments

        Cenp-CT:Avic\GFP-EYFP restores normal centromere clustering in the oocytes of Cenp-CZ3-4375/Cenp-CIR35 females.

        (Unhavaithaya and Orr-Weaver, 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        K. Dej T. Orr-Weaver

        (Heeger et al., 2005)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Cenp-CIR35
        (Fellmeth et al., 2023, Das et al., 2016)
        cenp-CIR35
        (Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013)
        l(3)85AaIR35
        (Heeger et al., 2005)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)