FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ThorUAS.cTa
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General Information
Symbol
Dmel\ThorUAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0190749
Feature type
allele
Associated gene
Dmel\Thor
Associated Insertion(s)
Carried in Construct
P{UAS-Thor.T}
Key Links
Transgenic product class
wild_type
(Tettweiler et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tettweiler et al., 2005)
Mutagen
in vitro construct
(Tettweiler, 2005, Tettweiler et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Thor.T}
Cytology
Description

UAS regulatory sequences drive expression of Thor coding sequences.

(Tettweiler et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Thor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ectopic expression of ThorScer\UAS.cTa, under the control of Scer\GAL4Act5C can completely suppress the sensitivity of foxo21/foxo25 flies to oxidative stress (median life-span of 56.8 hours, 39.7% survival rate after 60 hours exposure to 5% hydrogen peroxide).

      (Tettweiler et al., 2005)

      The foxounspecified lifespan phenotype can be rescued through overexpression of ThorScer\UAS.cTa (under the regulation of Scer\GAL4Act5C) to wild-type levels (median life-span of 27 hours), indicating that Thor may mediate nutritional stress resistance downstream of foxo.

      (Tettweiler, 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ThorUAS.cTa/Scer\GAL4hs.PB rescues ThorΔ1034-2617

      (Tettweiler et al., 2005)
      Comments

      Expression of ThorScer\UAS.cTa under the control of Scer\GAL4hs.PB rescues the increased sensitivity of ThorΔ1034-2617 larvae to starvation. Expression of ThorScer\UAS.cTa under the control of Scer\GAL4hs.PB rescues oxidative stress sensitivity (median life-span of 55.4 hours).

      (Tettweiler et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ThorScer\UAS.cTa
      ThorUAS.cTa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)