FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Cp1901
Open Close
General Information
Symbol
Dmel\Cp1901
Species
D. melanogaster
Name
FlyBase ID
FBal0191421
Feature type
allele
Associated gene
Dmel\Cp190
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Butcher et al., 2004)
Mutagen
ethyl methanesulfonate
(Butcher et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cp1901, Cp1901/Df(3R)P280-NR27 and Cp1901/Cp1902 mutants show some larval mortality, but approximately half the mutants survive until late pupal stages, dying as pharate adults. The eyes, wings and cuticle of Cp1901 pharate adults appear normal, showing that tissue organization is not affected by a major defect in mitosis. Additionally, there are no observable meiotic defects in Cp1901 larval testes.

      (Butcher et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A single copy of Cp1901 is sufficient to impair Fab-860.85.1 enhancer blocking (as shown by increased eye pigmentation).

      (Mohan et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3R)P280-NR27/Cp1901 is rescued by Cp190Ubi-p63E.PB

      (Butcher et al., 2004)

      Cp1901 is rescued by Cp190Ubi-p63E.PB

      (Butcher et al., 2004)
      Partially rescued by

      Cp1901 is partially rescued by Cp190ΔM.Ubi-p63E

      (Butcher et al., 2004)
      Comments

      The Cp190ΔM.Ubi-p63E transgene rescues the lethality of Cp1901 mutants so that ~80% of flies survive to adulthood. However, these adults are unhealthy and only survive for a few days.

      (Butcher et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CP1901
      (Zhang et al., 2024)
      Cp1901
      (Bartkuhn et al., 2009, Mohan et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)