FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GstS1M26
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General Information
Symbol
Dmel\GstS1M26
Species
D. melanogaster
Name
FlyBase ID
FBal0191829
Feature type
allele
Associated gene
Dmel\GstS1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Whitworth et al., 2005)
Mutagen
P-element activity
(Whitworth et al., 2005)
Progenitor genotype
GstS1EP1227
(Whitworth et al., 2005)
Cytology
Description

GstS1M26 was generated through excision of GstS1EP1227 a genomic deletion that removes most of the GstS1 locus.

(Whitworth et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cTa
      (Trinh et al., 2008)
      ameliorates  epilepsy
      modeled by paraShu
      (Chen et al., 2020)
      modeled by paraGEFS+
      (Chen et al., 2020)
      modeled by parabss1
      (Chen et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GstS1M26 mutants do not exhibit detectable neuron loss.

      (Trinh et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      GstS1M26 is an enhancer of abnormal neuroanatomy phenotype of Hsap\SNCAUAS.cTa, Scer\GAL4ple.PF

      (Trinh et al., 2008)

      GstS1M26 is an enhancer of abnormal neuroanatomy phenotype of park25

      (Whitworth et al., 2005)
      Other
      Statement
      Reference

      park25/Df(2R)ED1, GstS1M26 has short lived phenotype

      (Whitworth et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      GstS1M26 is an enhancer of dopaminergic neuron phenotype of Hsap\SNCAUAS.cTa, Scer\GAL4ple.PF

      (Trinh et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      park25 mutants bearing the GstS1M26 mutation in trans with Df(2R)ED1 (in which GstS1 is deleted) are recovered at low frequency and display a dramatically shortened lifespan. Analysis of DA neuron integrity in 1-day old park25 mutants bearing this combination of GstS1 alleles reveals significantly enhanced DA neuron loss relative to park25 mutants. Loss of GstS1 function alone has no affect on DA neuron viability in 1-day old adults.

      (Whitworth et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      A GstS1M26 mutant background enhances the DA neuron loss found in flies expressing Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF.

      (Trinh et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      H.Benes

      (Whitworth et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      GstS1M26
      (Chen et al., 2020, Trinh et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)