FlyBase Allele Report: Hsap\PARK7[UAS.cYa]

General Information

Symbol

Hsap\PARK7^UAS.cYa

Species

H. sapiens

Name

FlyBase ID

FBal0191987

Feature type

allele

Associated gene

Hsap\PARK7

Associated Insertion(s)

Carried in Construct

P{UAS-hDJ-1}

Also Known As

UAS-hDJ-1

Key Links

Transgenic product class

wild_type

(Yang et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yang et al., 2005)

Mutagen

in vitro construct

(Yang et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-hDJ-1}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\PARK7 coding sequences.

(Yang et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PARK7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^UAS.cVa

(Venderova et al., 2009)

modeled by Hsap\LRRK2^I2020T.UAS

(Venderova et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Expression of Hsap\PARK7^Scer\UAS.cYa results in a complex interaction with the Hsap\LRRK2^Scer\UAS.cVa and Hsap\LRRK2^{I2020T.Scer\UAS} Parkinson's Disease models; some aspects of the eye phenotype (black lesions) are suppressed, whereas others (such as eye pigmentation) are not.

(Venderova et al., 2009)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Venderova et al., 2009)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Venderova et al., 2009)

Detailed Description

Statement

Reference

Flies expressing Hsap\PARK7^Scer\UAS.cYa under the control of Scer\GAL4^GMR.PF at 29[o]C show loss of pigmentation in the eyes. The eyes are also rough.

(Venderova et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of abnormal locomotor behavior | adult stage phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\PARK7^UAS.cYa, Scer\GAL4^GMR.PF is a suppressor | partially of increased cell death phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^GMR.PF

(Yang et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Hsap\PARK7^UAS.cYa is a non-suppressor of short lived phenotype of Chchd2^null

(Meng et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\PARK7^UAS.cYa, Scer\GAL4^Ddc.PL is a suppressor of dopaminergic neuron | adult stage | progressive phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^Ddc.PL

(Faust et al., 2009)

Hsap\PARK7^UAS.cYa, Scer\GAL4^GMR.PF is a suppressor | partially of eye photoreceptor cell phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^GMR.PF

(Yang et al., 2005)

Hsap\PARK7^UAS.cYa, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^GMR.PF

(Yang et al., 2005)

Hsap\PARK7^UAS.cYa, Scer\GAL4^GMR.PF is a suppressor | partially of ommatidium phenotype of DJ-1α^RNAi.UAS, Scer\GAL4^GMR.PF

(Yang et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The expression of Hsap\PARK7^Scer\UAS.cYa under the control of Scer\GAL4^da.PU does not suppress the decreased life-span of Chchd2^null hemizygous males.

(Meng et al., 2017)

The accelerated age-dependent loss of dopaminergic neurons as well as the decrease in climbing ability in aged adults characteristic for flies expressing DJ-1α^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Ddc.PL (reared on a yeast-paste diet) is rescued by co-expression of Hsap\PARK7^Scer\UAS.cYa.

(Faust et al., 2009)

Co-expression of Hsap\DJ-1A^Scer\UAS.cYa with DJ-1α^{dsRNA.Scer\UAS}, under the regulation of Scer\GAL4^GMR.PF partially suppresses the eye degeneration phenotype observed in DJ-1α^{dsRNA.Scer\UAS} (Scer\GAL4^GMR.PF) mutants.

(Yang et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\DJ-1A^Scer\UAS.cYa

Hsap\PARK7^Scer\UAS.cYa

Hsap\PARK7^UAS.cYa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close