FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\loboMB00722
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General Information
Symbol
Dmel\loboMB00722
Species
D. melanogaster
Name
FlyBase ID
FBal0192494
Feature type
allele
Associated gene
Dmel\lobo
Associated Insertion(s)
Mi{ET1}loboMB00722
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Yang et al., 2011)

    hypomorphic allele - molecular evidence

    (Yang et al., 2011)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}loboMB00722
    Cytology
    Description

    Mi{ET1}loboMB00722 is inserted between E378 and Y379 (between GTTGT and ACTCA) and produces a 378 amino acid truncated polypeptide of the full-length protein of 897 amino acids.

    (Yang et al., 2011)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        In contrast to wild-type sperm, sperm from lobolobo/loboMB00722 males show increased frequencies of head-leading orientation during entry into the proximal seminal receptacle (PSR) and excessive flagellar folding in the PSR lumen. Mutant sperm also show excessive folding into tangles in the PSR. At later time points (1-4 hours after mating), the phenotype is more severe with mostly tangled flagella in the PSR lumen, and the number of mutant sperm that entering the distal seminal receptacle reduced by 100-fold.

        In contrast to wild type, the number of lobolobo/loboMB00722 sperm that enter the distal seminal receptacle (DSR) vary greatly on an individual basis and the average number of sperm stored per female per mating is only 4. Only 3.9 F1 progeny are produced per female from matings to these mutant males.

        Sperm from lobolobo/loboMB00722 males show head-leading orientation when they exit the proximal seminal receptacle, as wild type.

        (Yang et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Sperm from lobolobo/loboMB00722; Pkd2ko67 / Pkd2MB06703 double mutants are motile, are produced in large numbers and can enter the uterus as normal. However, in contrast to wild type, the number of sperm that enter the distal seminal receptacle (DSR) vary greatly on an individual basis and the average number of sperm stored per female per mating is only 2.4. Only 2.9 F1 progeny are produced per female from matings to these double-mutant males.

        Stored sperm from lobolobo/loboMB00722; Pkd2ko67 / Pkd2MB06703 double mutant males can exit the distal seminal receptacle and fertilize the egg.

        (Yang et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Excision of the Mi element reverts the mutant phenotype.

        (Yang et al., 2011)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        CG13661MB00722
        (Bellen, 2006.10.10)
        CG34110MB00722
        (Yang et al., 2011)
        CT33090MB00722
        (Bellen, 2006.10.10)
        loboMB00722
        Name Synonyms
        Secondary FlyBase IDs
          References (3)