FlyBase Allele Report: Dmel\dco[5B2.6]

General Information

Symbol

Dmel\dco^5B2.6

Species

D. melanogaster

Name

FlyBase ID

FBal0194119

Feature type

allele

Associated gene

Dmel\dco

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Strutt et al., 2006)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: R192H.

(Strutt et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:31,057,277..31,057,277 [-]

Nucleotide change:

G31057277A

Amino acid change:

Reported amino acid change:

R192H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Strutt et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with dco²)

(Strutt et al., 2006)

viable (with dco²)

(Strutt et al., 2006)

Phenotype Manifest In

ommatidium (with dco²)

(Strutt et al., 2006)

wing hair (with dco²)

(Strutt et al., 2006)

Detailed Description

Statement

Reference

The wings of dco²/dco^5B2.6 flies show polarity defects in the region proximal to the anterior cross vein. The eyes of these transheterozygotes also show significant polarity defects.

(Strutt et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dco²/dco^5B2.6 has abnormal cell polarity phenotype, enhanceable by pk[+]/pk^pk-sple-13

(Strutt et al., 2006)

Enhancer of

Statement

Reference

dco[+]/dco^5B2.6 is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

dco²/dco^5B2.6 has wing hair phenotype, enhanceable by pk[+]/pk^pk-sple-13

(Strutt et al., 2006)

Enhancer of

Statement

Reference

dco[+]/dco^5B2.6 is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The ommatidial polarity defects of fz¹⁹/fz²⁰ mutants are enhanced in fz¹⁹/fz²⁰, dco^5B2.6/+ double mutants.

pk^pk-sple-13/+; fz¹⁹/fz²⁰ flies show an enhancement of the wing polarity defects seen in fz¹⁹/fz²⁰ flies.

(Strutt et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dco²

(Strutt et al., 2006)

Rescued by

dco²/dco^5B2.6 is rescued by dco^Act5C.EGFP

(Strutt et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a modifier of a hypomorphic fz phenotype in the eye.

(Strutt et al., 2006)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

5B2.6

(Strutt et al., 2006)

dco^5B2.6

(Strutt et al., 2019, Strutt et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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