FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dco2
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General Information
Symbol
Dmel\dco2
Species
D. melanogaster
Name
FlyBase ID
FBal0032015
Feature type
allele
Associated gene
Dmel\dco
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zilian et al., 1999)
Mutagen
ethyl methanesulfonate
(Jursnich et al., 1990)
Progenitor genotype
Cytology
Description

The mutated residue G175 is strictly conserved in, and specific for, the CKI kinase family. G175 falls in the L-9D loop. This lesion may weaken or prevent the interaction with at least some of the dco substrates, without affecting its catalytic activity.

(Zilian et al., 1999)

Amino acid replacement: G175S.

(Zilian et al., 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,057,329..31,057,329 [-]
Nucleotide change:

G31057329A

Amino acid change:

G175S | dco-PA; G175S | dco-PB; G175S | dco-PC; G175S | dco-PD; G175S | dco-PE

Reported amino acid change:

G175S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zilian et al., 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wings of dco2/dco5B2.6 flies show polarity defects in the region proximal to the anterior cross vein. The eyes of these transheterozygotes also show significant polarity defects.

      (Strutt et al., 2006)

      dco3 in combination with dco2 or dco18 : lethality in larval or early pupal stages, with overgrown discs. dco2 in combination with dco18 : show lethality during larval or early pupal stages, discless phenotype. dco2 in combination with dcole88 : show lethality during larval or early pupal stages. dco2 in combination with dcoi3-193 or dcoS139602 : show lethality during larval or early pupal stages, with abnormal discs with granular zone and abnormal folding. dco2 in combination with dcoS053813 : show lethality during larval or early pupal stages with small discs. dco2 in combination with dcoS091510 : show lethality during early or late pupal stages, with abnormal discs with granular zone and abnormal folding. dco2 in combination with dcoP103 : adult viable with expanded wings and leg outgrowths. dco2 in combination with dcoS144701 : adult viable with normal phenotype.

      (Zilian et al., 1999)

      When raised at 25oC the larval period of dco2 flies in heteroallelic combinations is greatly extended and they develop overgrown imaginal discs. Imaginal discs show gap-junctional communication defects: coupling is severely diminished. The single layer epithelium is maintained during overgrowth and they differentiate into the correct but abnormal adult structures. Embryos are smaller than wild type at 4-5 days after egg laying: ventral and dorsal arms and ventral plates of head skeleton are reduced.

      (Jursnich et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      dco2/dco5B2.6 has abnormal cell polarity phenotype, enhanceable by pk[+]/pkpk-sple-13

      (Strutt et al., 2006)
      Enhancer of
      Statement
      Reference

      dco2/dco[+] is an enhancer of abnormal cell polarity phenotype of fz20/fz19

      (Strutt et al., 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      dco2/dco5B2.6 has wing hair phenotype, enhanceable by pk[+]/pkpk-sple-13

      (Strutt et al., 2006)
      Enhancer of
      Statement
      Reference

      dco2/dco[+] is an enhancer of ommatidium phenotype of fz20/fz19

      (Strutt et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ommatidial polarity defects of fz19/fz20 mutants are enhanced in fz19/fz20, dco2/+ double mutants.

      pkpk-sple-13/+; fz19/fz20 flies show an enhancement of the wing polarity defects seen in fz19/fz20 flies.

      (Strutt et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Separable from: an undefined, linked embryonic lethal mutation.

      (Zilian et al., 1999)
      Comments
      Comments

      Allelic series in order of decreasing strength: dcole88 > dco18 > dco2.

      (Zilian et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dco2
      (Ray and Lakhotia, 2019, Strutt et al., 2019, Kelly et al., 2016, Strutt et al., 2006, Zhang et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)