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General Information
Symbol
Dmel\dcoS091510
Species
D. melanogaster
Name
FlyBase ID
FBal0100078
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dcoP915
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of P{lacW} into the second (5' UTR) intron of the dco transcription unit, 766bp downstream of its 5' end.

Insertion components
P{lacW}dcoS091510
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dcoS091510/dcoS139602 hypomorphs are developmentally delayed. They exhibit a dramatic increase in apoptosis in the wing discs compared to wild-type. Elevated apoptosis (assessed through the use of TUNEL) is also found in the leg and haltere discs, while no increase is detected in the eye imaginal discs.

Homozygotes show lethality during larval or early pupal stages, abnormal discs with granular zone and abnormal folding. dco3 in combination with dcole88, dcoi3-193, dcoS053813, dcoS139602, dcoS091510 and dcoP103 : show lethality during larval or early pupal stages with typical dco3 phenotype (swollen tarsi with or without head defects). Discs overgrown. dco18 in combination with dcoS139602 or dcoS091510 : show lethality during larval or early pupal stages with a discless phenotype. dcole88 in combination with dcoS091510 : show lethality during larval or early pupal stages with a small discs phenotype. dcoi3-193 in combination with dcoS091510 : show lethality during larval or early pupal stages with small discs phenotype. dcoS053813 in combination with dcoS091510 : show lethality during larval or early pupal stages with a small disc phenotype. dcoS139602 in combination with dcoS091510 : show lethality during larval or early pupal stages, normal discs. dcoS091510 in combination with dcoP103 : adult viable with normal phenotype, normal discs. dcoS091510 in combination with dcoS144701 : adult viable with normal phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Levels of apoptosis in dcoS091510/dcoS139602 hypomorphs are reduced in a Df(3L)H99 background. This is correlated with marked acceleration in disc growth and larval development (from 8-10 days to 5-6 days). These Df(3L)H99/+, dcoS091510/dcoS139602 animals have increased survival into late pupal stages, and the veination pattern of the majority of these animals is simlar to wild-type. Occasional escapers survive to adulthood and display normal legs and wrinkled or blistered wings. These results suggest that the developmental delay in disc growth and larval development seen in dcoS091510/dcoS139602 mutants is largely caused by elevated apoptosis.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Allelic series in order of decreasing strength: dcoS053813 > dcoS139602 > dcoS091510 > dcoP103 > dcoS144701.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)