FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kirreΔ610-959.UAS.Tag:FLAG
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General Information
Symbol
Dmel\kirreΔ610-959.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0194328
Feature type
allele
Associated gene
Dmel\kirre
Associated Insertion(s)
Carried in Construct
P{UAS-kirre.NT(TM)flag}
Key Links
Transgenic product class
inframe_deletion
(Menon et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Menon et al., 2005)
Mutagen
in vitro construct
(Menon et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-kirre.NT(TM)flag}
Cytology
Description

UASt regulatory sequences drive expression of the kirre coding sequence lacking amino acids 610-959 (the intracellular region) and containing a COOH-terminal Tag:FLAG tag.

(Menon et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
kirre
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4how-24B does not have dominant negative effects.

      (Menon et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      kirreΔ610-959.UAS.Tag:FLAG/Scer\GAL4how-24B rescues Df(1)w67k30

      (Menon et al., 2005)

      kirreΔ610-959.UAS.Tag:FLAG/Scer\GAL4wg.PM rescues Df(1)w67k30

      (Menon et al., 2005)

      kirreΔ610-959.UAS.Tag:FLAG, Scer\GAL4how-24B, kirreΔ103-553.UAS.Tag:FLAG rescues Df(1)w67k30

      (Menon et al., 2005)
      Partially rescues

      kirreΔ610-959.UAS.Tag:FLAG/Scer\GAL4how-24B partially rescues Df(1)w67k30

      (Bulchand et al., 2010)
      Fails to rescue

      kirreΔ610-959.UAS.Tag:FLAG/Scer\GAL4sns.GCN fails to rescue kirresps-1

      (Helmstadter et al., 2012)

      kirreΔ610-959.UAS.Tag:FLAG/Scer\GAL4how-24B fails to rescue Df(1)w67k30

      (Menon et al., 2005)

      kirreΔ610-959.UAS.Tag:FLAG, Scer\GAL4how-24B, kirreΔ103-553.UAS.Tag:FLAG fails to rescue Df(1)w67k30

      (Menon et al., 2005)
      Comments

      Expression of kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4sns.GCN fails to rescue the garland cell phenotype associated with kirresps-1 mutants.

      (Helmstadter et al., 2012)

      Expression of kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4how-24B only restores fusion competent myoblast (FCM) fusion up to the five-nuclear stage in Df(1)w67k30 mutant embryos.

      (Bulchand et al., 2010)

      Expression of kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4how-24B or Scer\GAL4wg.PM restores the ability of myoblast founders to attract and adhere to fusion-competent myoblasts in Df(1)w67k30 mutant embryos. However, in embryos expressing kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4how-24B, only a small degree of myoblast fusion occurs and most of the DA1 muscles develop into bi-nucleated precursors.

      Co-expression of kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG and kirreΔ103-553.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4how-24B restores the ability of myoblast founders to attract fusion-competent myoblasts in Df(1)w67k30 mutant embryos. However, myoblast fusion stalls after precursors form.

      (Menon et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG
      kirreΔ610-959.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)