FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\brpUAS.cWa
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General Information
Symbol
Dmel\brpUAS.cWa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Wagh
FlyBase ID
FBal0194771
Feature type
allele
Associated gene
Dmel\brp
Associated Insertion(s)
Carried in Construct
P{UAS-brp.W}
Also Known As
UAS-brp
Key Links
Transgenic product class
cDNA
(Wagh et al., 2006)
wild_type
(Wagh et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wagh et al., 2006)
wild_type
(Wagh et al., 2006)
Mutagen
in vitro construct
(Kittel et al., 2006, Wagh et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-brp.W}
Cytology
Description

UASt regulatory sequences drive expression of the 5'UTR and coding regions of brp (these correspond to cDNA AT09405).

(Wagh et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
brp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  nervous system disease
      modeled by unc-104bris
      (Zhang et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4RapGAP1-OK6/brpUAS.cWa partially rescues brp69/Df(2R)BSC29

      (Kittel et al., 2006)

      Scer\GAL4elav-C155/brpUAS.cWa partially rescues brp69/Df(2R)BSC29

      (Kittel et al., 2006)
      Comments

      Expression of the brpScer\UAS.cWa transgene, under the control of either Scer\GAL4OK6 or Scer\GAL4elav-C155, rescues the larval lethality of brp69/Df(2R)BSC29 mutants. In addition, Scer\GAL4OK6>brpScer\UAS.cWa expression partially restores the lack of T-bars seen in these mutants, although T-bars in the rescued flies are somewhat aberrant in shape. Expression of the transgene with both drivers can partially rescue the drop in current amplitude from brp69/Df(2R)BSC29 NMJs.

      (Kittel et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      brpScer\UAS.cWa
      brpUAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wagh
      Secondary FlyBase IDs
        References (6)