FlyBase Allele Report: Dmel\unc-104[d11204]

General Information

Symbol

Dmel\unc-104^d11204

Species

D. melanogaster

Name

FlyBase ID

FBal0158538

Feature type

allele

Associated gene

Dmel\unc-104

Associated Insertion(s)

P{XP}unc-104^d11204

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

P{XP}unc-104^d11204

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{XP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,756,584..16,756,584 [-]

(Li et al., 2017, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage (with unc-104^bris)

(Kern et al., 2013)

abnormal neuroanatomy | third instar larval stage (with unc-104^bris)

(Kern et al., 2013)

lethal - all die during third instar larval stage (with unc-104^bris)

(Kern et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Initial neurite outgrowth in unc-104^bris/unc-104^d11204 embryos is unimpaired: no gross morphological alterations of the peripheral sensory neuron system (dendrites/axons) are observed in stage 16 embryos.

unc-104^bris/unc-104^d11204 larvae do not display dystonic posterior paralysis.

unc-104^bris/unc-104^d11204 larvae are almost paralysed and display a body posture defect.

Neuromuscular junctions of unc-104^bris/unc-104^d11204 larvae are longer but not larger than those in controls, and mutant NMJs consist of more but smaller synaptic boutons than controls.

(Kern et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

unc-104^bris/unc-104^d11204 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.B.UAS

(Kern et al., 2013)

unc-104^bris/unc-104^d11204 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.C.UAS

(Kern et al., 2013)

NOT suppressed by

Statement

Reference

unc-104^bris/unc-104^d11204 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/brp^UAS.cWa

(Kern et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

unc-104^bris/unc-104^d11204 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.B.UAS

(Kern et al., 2013)

unc-104^bris/unc-104^d11204 has bouton | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.B.UAS

(Kern et al., 2013)

unc-104^bris/unc-104^d11204 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.C.UAS

(Kern et al., 2013)

unc-104^bris/unc-104^d11204 has bouton | third instar larval stage phenotype, non-enhanceable by Scer\GAL4^elav-C155/brp^RNAi.C.UAS

(Kern et al., 2013)

NOT suppressed by

Statement

Reference

unc-104^bris/unc-104^d11204 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/brp^UAS.cWa

(Kern et al., 2013)

unc-104^bris/unc-104^d11204 has bouton | third instar larval stage phenotype, non-suppressible by Scer\GAL4^elav-C155/brp^UAS.cWa

(Kern et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

unc-104^bris/unc-104^d11204 is rescued by Scer\GAL4^elav-C155/unc-104^UAS.mCherry

(Kern et al., 2013)

Partially rescued by

unc-104^bris/unc-104^d11204 is partially rescued by Scer\GAL4^elav-C155/unc-104^UAS.mCherry

(Kern et al., 2013)

Comments

Scer\GAL4^elav-C155-mediated expression of unc-104^{Scer\UAS.T:Disc\RFP-mCherry} rescues the lethality, impaired locomotion, and defective body posture of unc-104^bris/unc-104^d11204 larvae. The defective apposition of active zones and post-synaptic densities of unc-104^bris/unc-104^d11204 larvae is partially rescued. The neuromuscular junction morphology defects of unc-104^bris/unc-104^d11204 larvae are rescued by Scer\GAL4^elav-C155-mediated, but not Scer\GAL4^how-24B-mediated expression of unc-104^{Scer\UAS.T:Disc\RFP-mCherry}.

(Kern et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

19346

w¹¹¹⁸; P{XP}unc-104^d11204/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

unc-104^d11024

(Zhang et al., 2016)

unc-104^d11204

(Ribot et al., 2022, White et al., 2020, Li et al., 2017, Kern et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close