FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\laza22
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General Information
Symbol
Dmel\laza22
Species
D. melanogaster
Name
FlyBase ID
FBal0197218
Feature type
allele
Associated gene
Dmel\laza
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Garcia-Murillas et al., 2006)
Progenitor genotype
lazaEY04417
(Garcia-Murillas et al., 2006)
Cytology
Description

Imprecise excision of the insertion in lazaEY04417 resulting in a 703bp deletion that removes the presumed start codon and sequences encoding the first 28 amino acids of the encoded protein.

(Garcia-Murillas et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      laza22 photoreceptors show normal ultrastructure on eclosion. However, when laza22 flies are raised in bright light, the mutant photoreceptors undergo progressive vesiculation and degeneration of the rhabdomeres which is quite severe by 5 days after eclosion. This degeneration is not seen if the laza22 flies are raised in dim light.

      (Garcia-Murillas et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      laza22 is a suppressor of abnormal neurophysiology phenotype of rdgA3

      (Garcia-Murillas et al., 2006)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      laza22/laza22 is a suppressor | partially of retina | adult stage | progressive | conditional phenotype of Pld3.1

      (Thakur et al., 2016)

      laza22/laza22 is a suppressor | partially of ommatidium | adult stage | progressive | conditional phenotype of Pld3.1

      (Thakur et al., 2016)

      laza22/laza22 is a suppressor of eye photoreceptor cell phenotype of rdgA3

      (Garcia-Murillas et al., 2006)

      laza[+]/laza22 is a suppressor of eye photoreceptor cell phenotype of rdgA3

      (Garcia-Murillas et al., 2006)

      laza22 is a suppressor of retina phenotype of rdgA3

      (Garcia-Murillas et al., 2006)

      laza22 is a suppressor of eye photoreceptor cell phenotype of rdgB9

      (Garcia-Murillas et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The light-dependent retinal degeneration observed in Pld3.1 homozygous adults is partially suppressed by combination with laza22 in homozygous state.

      (Thakur et al., 2016)

      rdgA3 ; laza22 double mutant adults show photoreceptor degeneration in dim light, with the rate of degeneration being similar to that seen in rdgA3 single mutants. When flies are raised in bright light, the rate of photoreceptor degeneration in rdgA3 ; laza22/laza22 double mutants is greatly reduced compared to that seen in rdgA3 single mutants. The rate of photoreceptor degeneration in rdgA3 ; laza22/+ flies in bright light is intermediate between that of rdgA3 ; laza22/laza22 and rdgA3 flies.

      The decreased rate of deactivation of the light response that is seen in the electroretinogram response of rdgA3 flies following a 1 second stimulus of light is substantially rescued by laza22.

      laza22 slows the rate of photoreceptor degeneration seen in rdgB9 flies.

      (Garcia-Murillas et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      laza22
      (Thakur et al., 2016, Garcia-Murillas et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)