FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aurA17961
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General Information
Symbol
Dmel\aurA17961
Species
D. melanogaster
Name
FlyBase ID
FBal0197865
Feature type
allele
Associated gene
Dmel\aurA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wang et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: D334N.

(Lee et al., 2006)

Amino acid replacement: D344N.

(Wang et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:11,964,447..11,964,447 [+]
Nucleotide change:

G11964447A

Amino acid change:

E344K | aurA-PA

Reported amino acid change:

D344N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Nature of mutation inferred by FlyBase curator. Residue 344 is Glu (GAG) rather than Asp (GAT/C). The G to A mutation that would have given rise to the reported D344N mutation in the published strain would lead to an E344K mutation in the sequenced strain.

(Lee et al., 2006, Wang et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Metaphase to anaphase transition is delayed in aurA17961/aurA14641 transheterozygous larval brain neuroblasts.

      (Caous et al., 2015)

      Mutants show a massive increase in larval brain neuroblasts, developing more than 1000 central brain neuroblasts at stages where wild-type larvae have only 95-100 neuroblasts.

      (Lee et al., 2006)

      Homozygous larvae have supernumerary neuroblasts. The mitotic spindle is often misoriented relative to the mira protein crescent in the mutant neuroblasts, in contrast to wild-type where the spindle is always aligned perpendicular to the mira protein crescent.

      (Wang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Phenotype Manifest In
      NOT Enhanced by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased neuroblast number and mitotic index seen in aurA8839/aurA17961 transheterozygote larvae is not enhanced by combination with BubR1KEN.T:Disc\RFP-mRFP,BubR1k06109 (the mitotic index in the double mutants is even slightly decreased), whereas the rate of ploidy defects is increased compared to either of the single gene mutants.

      (Caous et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      aur17961
      (Wang et al., 2006)
      aurA17961
      (Caous et al., 2015, Lee et al., 2006)
      l(3)LL-17961
      (Lee et al., 2006)
      l(3)LL17961
      (Wang et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)