FlyBase Allele Report: Dmel\GILT2[GD4844]

General Information

Symbol

Dmel\GILT2^GD4844

Species

D. melanogaster

Name

FlyBase ID

FBal0198917

Feature type

allele

Associated gene

Dmel\GILT2

Associated Insertion(s)

Carried in Construct

P{GD4844}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4844}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4844

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^c564

(Kongton et al., 2014)

abnormal immune response, with Scer\GAL4^He.PZ

(Kongton et al., 2014)

abnormal immune response, with Scer\GAL4^r4

(Kongton et al., 2014)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing CG10157^GD4844 via Scer\GAL4^c564, Scer\GAL4^He.PZ or Scer\GAL4^r4 show higher bacterial load levels compared to wild type after injection with Gram-negative bacteria.

(Kongton et al., 2014)

Adults expressing GILT2^GD4844 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4844

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

GILT1^KG01492, GILT2^GD4844, Scer\GAL4^c564 has abnormal immune response phenotype

(Kongton et al., 2014)

GILT1^KG01492, GILT2^GD4844, Scer\GAL4^r4 has abnormal immune response phenotype

(Kongton et al., 2014)

GILT1^KG01492, GILT2^GD4844, Scer\GAL4^Cg.PA has abnormal immune response phenotype

(Kongton et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Flies expressing CG10157^GD4844 via Scer\GAL4^c564, Scer\GAL4^Cg.PA or Scer\GAL4^r4 show higher bacterial load levels compared to wild type after injection with Gram-negative bacteria.

Flies expressing CG10157^GD4844 via Scer\GAL4^c564, Scer\GAL4^Cg.PA or Scer\GAL4^r4 in a CG9796^KG01492 background show higher bacterial load levels compared to wild type or either single mutant condition after injection with Gram-negative bacteria.

(Kongton et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v12909

w¹¹¹⁸; P{GD4844}v12909

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4844

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG10157^GD4844

GILT2^GD4844

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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