FlyBase Allele Report: Dmel\Mfap1[GD5122]

General Information

Symbol

Dmel\Mfap1^GD5122

Species

D. melanogaster

Name

FlyBase ID

FBal0198925

Feature type

allele

Associated gene

Dmel\Mfap1

Associated Insertion(s)

Carried in Construct

P{GD5122}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD5122}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD5122

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

(Andersen and Tapon, 2008)

wing pouch | somatic clone, with Scer\GAL4^Act5C.PP

(Andersen and Tapon, 2008)

Detailed Description

Statement

Reference

Expression of Mfap1^GD5122 under the control of Scer\GAL4^ppk.PG does not cause any defects in the formation of the dendritic arbor of the class IV dendritic arborizing neuron neither does it interfere with the dendrite pruning during the pupal stage.

(Rode et al., 2017)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in extreme defects in the shape of neuroblasts in the larval brain.

(Neumüller et al., 2011)

Adults expressing Mfap1^GD5122 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing Mfap1^GD5122 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality before the pupal stage.

(Mummery-Widmer et al., 2009)

Ubiquitous expression of Mfap1^GD5122 under the control of Scer\GAL4^unspecified results in larval lethality.

Homozygous clones in the wing disc that are expressing Mfap1^GD5122 under the control of Scer\GAL4^Act5C.PP are markedly smaller than control clones. Apoptosis is seen in the wing pouch in these mutant clones.

(Andersen and Tapon, 2008)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5122

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Mfap1^GD5122, Scer\GAL4^ppk.PG is a non-enhancer of abnormal neuroanatomy | pupal stage phenotype of Scer\GAL4^ppk.PG, TER94^{E375Q.E575Q.UAS}

(Rode et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Mfap1^GD5122, Scer\GAL4^ppk.PG is a non-enhancer of larval multidendritic class IV neuron | pupal stage phenotype of Scer\GAL4^ppk.PG, TER94^{E375Q.E575Q.UAS}

(Rode et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The dendrite pruning defects in class IV dendrite arborizing neurons observed in pupae expressing TER94^{E375Q.E575Q.Scer\UAS} under the control of Scer\GAL4^ppk.PG is not significantly affected by co-expression of Mfap1^GD5122.

(Rode et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v15610