FlyBase Allele Report: Dmel\meng[GD7239]

General Information

Symbol

Dmel\meng^GD7239

Species

D. melanogaster

Name

FlyBase ID

FBal0199328

Feature type

allele

Associated gene

Dmel\meng

Associated Insertion(s)

Carried in Construct

P{GD7239}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7239}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7239

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^salm.EPv

(Hevia et al., 2017)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

wing, with Scer\GAL4^nub.PU

(Hevia et al., 2017)

wing, with Scer\GAL4^salm.EPv

(Hevia et al., 2017)

wing vein, with Scer\GAL4^salm.EPv

(Hevia et al., 2017)

Detailed Description

Statement

Reference

The expression of CG11221^GD7239 under the control of Scer\GAL4^nub.PU (together with Dicer-2, for efficient RNAi) leads to folded wings, compared to controls; expression under the control of Scer\GAL4^salm.EPv leads to small and folded wings.

(Hevia et al., 2017)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in viable flies or late pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in lethality, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7239

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

meng^GD7239/Scer\GAL4^nub.PU is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

NOT Suppressor of

Statement

Reference

meng^GD7239, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of abnormal developmental rate | somatic clone | larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

meng^GD7239/Scer\GAL4^nub.PU is a suppressor of wing phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

NOT Suppressor of

Statement

Reference

meng^GD7239, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of eye-antennal disc | somatic clone | third instar larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

meng^GD7239, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of eye photoreceptor cell | somatic clone | third instar larval stage phenotype of Ras85D^G12V.UAS, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of CG11221^GD7239 (together with Dicer-2, for efficient RNAi) suppresses the oversized wing defects induced by the expression of Smox^{SDVD.Scer\UAS} under the control of Scer\GAL4^nub.PU.

(Hevia et al., 2017)

Co-expression of CG11221^GD7239 fails to suppress the reduction of differentiation seen in eye-antennal disc clones expressing both RhoGEF2^RE.Scer\UAS and Ras85D^{G12V.Scer\UAS} under the control of Scer\GAL4^tub.PU, and also fails to suppress the developmental delay shown by larvae containing these clones.

(Khoo et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v42947

w¹¹¹⁸; P{GD7239}v42947

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7239

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11221^GD7239

meng^GD7239

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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