FlyBase Allele Report: Dmel\Dad1[GD1006]

General Information

Symbol

Dmel\Dad1^GD1006

Species

D. melanogaster

Name

FlyBase ID

FBal0200250

Feature type

allele

Associated gene

Dmel\Dad1

Associated Insertion(s)

Carried in Construct

P{GD1006}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1006}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1006

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

wing disc | third instar larval stage, with Scer\GAL4^en.PU

(Zhang et al., 2016)

Detailed Description

Statement

Reference

Expression of Dad1^GD1006 leads to increase in apoptosis and compensatory cell proliferation in the posterior compartment of the third instar larval wing discs (driven by Scer\GAL4^en.PU) and to smaller wings in adults (driven by Scer\GAL4^C5).

(Zhang et al., 2016)

Adults expressing l(2)k12914^GD1006 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1006

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, enhanceable by Stt3A[+]/Stt3A^KG03333

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, enhanceable by Stt3A[+]/Stt3A^KG03333

(Zhang et al., 2016)

NOT Enhanced by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, non-enhanceable by Stt3B^j2D9/Stt3B[+]

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, non-enhanceable by Stt3B^j2D9/Stt3B[+]

(Zhang et al., 2016)

Suppressed by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, suppressible | partially by bsk^GD10555, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, suppressible by hep^GD1461, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, suppressible by Mekk1^GD9945, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, suppressible by wnd^KK100521, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, suppressible | partially by bsk^GD10555, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, suppressible by hep^GD1461, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, suppressible by Mekk1^GD9945, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, suppressible by wnd^KK100521, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by bsk^GD10555, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by hep^GD1461, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by Mekk1^GD9945, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by wnd^KK100521, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by PEK^HMJ02063, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased cell death | third instar larval stage phenotype, suppressible by crc^JF02007, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased occurrence of cell division | third instar larval stage phenotype, suppressible by PEK^HMJ02063, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased occurrence of cell division | third instar larval stage phenotype, suppressible by crc^JF02007, Scer\GAL4^en.PU

(Zhang et al., 2016)

NOT suppressed by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, non-suppressible by Ask1^GD11408, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, non-suppressible by Tak1^KK108611, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased occurrence of cell division | third instar larval stage phenotype, non-suppressible by bsk^GD10555, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has increased occurrence of cell division | third instar larval stage phenotype, non-suppressible by hep^GD1461, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has abnormal size | adult stage phenotype, non-suppressible by slpr^KK100726, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, non-suppressible by Ask1^GD11408, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, non-suppressible by Tak1^KK108611, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has visible | adult stage phenotype, non-suppressible by slpr^KK100726, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, enhanceable by Stt3A[+]/Stt3A^KG03333

(Zhang et al., 2016)

NOT Enhanced by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, non-enhanceable by Stt3B^j2D9/Stt3B[+]

(Zhang et al., 2016)

Suppressed by

Statement

Reference

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, suppressible | partially by bsk^GD10555, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, suppressible by hep^GD1461, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, suppressible by Mekk1^GD9945, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, suppressible by wnd^KK100521, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by bsk^GD10555, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by hep^GD1461, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by Mekk1^GD9945, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by wnd^KK100521, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by PEK^HMJ02063, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, suppressible by crc^JF02007, Scer\GAL4^en.PU

(Zhang et al., 2016)

NOT suppressed by

Statement

Reference

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, non-suppressible by hep^GD1461, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, non-suppressible by Atf6^JF02109, Scer\GAL4^en.PU

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, non-suppressible by Ask1^GD11408, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, non-suppressible by Tak1^KK108611, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^cv-c-C5 has wing phenotype, non-suppressible by slpr^KK100726, Scer\GAL4^cv-c-C5

(Zhang et al., 2016)

Dad1^GD1006, Scer\GAL4^en.PU has wing disc | third instar larval stage phenotype, non-suppressible by bsk^GD10555, Scer\GAL4^en.PU

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The small wing size induced by Scer\GAL4^C5-controlled expression of Dad1^GD1006 is enhanced by Stt3A^KG03333 heterozygosity but not by Stt3B^j2D9 heterozygosity, whereas it is suppressed by the co-expression of either bsk^GD10555 (partially), hep^GD1461, Mekk1^GD9945 and wnd^KK100521, but not by the co-expression of either Ask1^GD11408, Tak1^KK108611, or slpr^KK100726.

The apoptosis induced in third instar larval wing discs by Scer\GAL4^en.PU-controlled expression of Dad1^GD1006 is suppressed by the co-expression of either bsk^GD10555, hep^GD1461, Mekk1^GD9945, wnd^KK100521, PEK^HMJ02063, or crc^JF02007, but not of Atf6[JF02109].

Also, the compensatory cell division induced in third instar larval wing discs by Scer\GAL4^en.PU-controlled expression of Dad1^GD1006 is partially suppressed by the co-expression of either PEK^HMJ02063 or crc^JF02007, but not by the expression of bsk^GD10555 or hep^GD1461.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v33164