FlyBase Allele Report: Dmel\crc[JF02007]

General Information

Symbol

Dmel\crc^JF02007

Species

D. melanogaster

Name

FlyBase ID

FBal0219991

Feature type

allele

Associated gene

Dmel\crc

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02007}

Also Known As

Atf4 RNAi, UAS-ATF4^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.1.15)

Mutagen

in vitro construct

(Perkins et al., 2009.1.15)

Progenitor genotype

Carried in construct

P{TRiP.JF02007}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02007

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Niccoli et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | male, with Scer\GAL4^Toll-6-D42

(Hunt et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of crc^JF02007 under the control of Scer\GAL4^Toll-6-D42 leads to climbing defects when compared to controls.

(Hunt et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

crc^JF02007, Scer\GAL4^elav.PU is a suppressor | partially of abnormal developmental rate phenotype of ProRS-m^VSH330525, Scer\GAL4^elav.PU

(Xu et al., 2026)

crc^JF02007, Scer\GAL4^elav.PU is a suppressor | partially of bang sensitive phenotype of ProRS-m^VSH330525, Scer\GAL4^elav.PU

(Xu et al., 2026)

crc^JF02007, Scer\GAL4^hh.PU is a suppressor | partially of increased cell death | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

crc^JF02007, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Scer\GAL4^nSyb.PS/crc^JF02007 is a suppressor | partially of majority die during pupal stage phenotype of Scer\GAL4^nSyb.PS, TFAM^UAS.cCa

(Hunt et al., 2019)

Scer\GAL4^Toll-6-D42/crc^JF02007 is a suppressor of abnormal locomotor behavior | male | adult stage phenotype of Scer\GAL4^Toll-6-D42, TFAM^UAS.cCa

(Hunt et al., 2019)

Scer\GAL4^Toll-6-D42/crc^JF02007 is a suppressor of visible | adult stage phenotype of Scer\GAL4^Toll-6-D42, TFAM^UAS.cCa

(Hunt et al., 2019)

crc^JF02007, Scer\GAL4^en.PU is a suppressor of increased cell death | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

crc^JF02007, Scer\GAL4^en.PU is a suppressor of increased occurrence of cell division | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

crc^JF02007, Scer\GAL4^hh.PU is a suppressor | partially of wing disc posterior compartment | larval stage phenotype of Paip1^GD13792, Scer\GAL4^hh.PU

(Xue et al., 2023)

crc^JF02007, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Scer\GAL4^Toll-6-D42/crc^JF02007 is a suppressor of wing phenotype of Scer\GAL4^Toll-6-D42, TFAM^UAS.cCa

(Hunt et al., 2019)

crc^JF02007, Scer\GAL4^en.PU is a suppressor of wing disc | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of crc^JF02007 under the control of Scer\GAL4^Toll-6-D42 alleviates climbing and wing inflation defects exhibited as a result of expression of TFAM^UAS.cCa under the control of Scer\GAL4^Toll-6-D42.

Expression of crc^JF02007 under the control of Scer\GAL4^nSyb.PS alleviates almost complete late pupal lethality exhibited as a result of expression of TFAM^UAS.cCa under the control of Scer\GAL4^nSyb.PS.

(Hunt et al., 2019)

Co-expression of crc^JF02007 suppresses the compensatory cell division (partially) and apoptosis induced by Scer\GAL4^en.PU-controlled expression of Dad1^GD1006 in third instar larval wing discs.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25985

y¹ v¹; P{TRiP.JF02007}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ATF4^JF02007

(Myers et al., 2022)

crc^JF02007

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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