FlyBase Allele Report: Dmel\parvin[GD3687]

General Information

Symbol

Dmel\parvin^GD3687

Species

D. melanogaster

Name

FlyBase ID

FBal0203358

Feature type

allele

Associated gene

Dmel\parvin

Associated Insertion(s)

Carried in Construct

P{GD3687}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD3687}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD3687

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval somatic muscle cell, with Scer\GAL4^Mef2.PR

(Langer et al., 2010, Schnorrer et al., 2010)

wing, with Scer\GAL4^elav.PLu

(Dietzl et al., 2007)

Detailed Description

Statement

Reference

Expression of CG32528^GD3687 under the control of Scer\GAL4^Mef2.PR results in early larval lethality with body muscles displaying a myospheroid (rounded muscles) phenotype. The larvae are also shorter in length than control larvae.

(Langer et al., 2010)

Adults expressing parvin^GD3687 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in rounded larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression of CG32528^GD3687 under the control of Scer\GAL4^elav.PLu results in abnormal wing posture and flight defects, in addition to semi-lethality.

(Dietzl et al., 2007)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

3687

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Mef2.PR, parvin^GD3687 has decreased body size | larval stage phenotype, suppressible by P{FlyFos-044975}

(Langer et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Mef2.PR, parvin^GD3687 has larval somatic muscle cell phenotype, suppressible by P{FlyFos-044975}

(Langer et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The myospheroid (rounded muscles) phenotype and growth defects seen in larvae expressing CG32528^GD3687 under the control of Scer\GAL4^Mef2.PR are rescued if they are carrying the P{FlyFos-044975} construct (which contains D. pseudoobscura pseudoobscura fosmid sequence that includes the region orthologous to CG32528).

(Langer et al., 2010)

Complementation and Rescue Data

Partially rescues

parvin^GD3687/Scer\GAL4^ptc.PU partially rescues parvin^KK102567

(Chountala et al., 2012)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v11670