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General Information
Symbol
Dmel\CTPsynGD4740
Species
D. melanogaster
Name
FlyBase ID
FBal0205229
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of CTPsynGD4740 under the control of Scer\GAL4c564 has no obvious affect on the inflammatory response to Gram-positive bacterial infection or under basal conditions, as compared to controls.

Expression of CTPsynGD4740 RNAi (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of either Scer\GAL455B or Scer\GAL4CY2 results in significant decrease in the proportion of follicle cells undergoing DNA replication replication (measured by BrU incorporation) in stage 9 egg chambers compared to controls. Expression under the Scer\GAL4CY2 driver also leads to reduced nuclear size in stage 10A egg chambers compared to controls.

Expression via "HHLT-gal4" or Scer\GAL4Hml.Δ results in loss of progenitor cells in the primary lobes of the larval lymph gland. ("HHLT-gal4" is a combination of Scer\GAL4HCH.Hand and Scer\GAL4Hml.Δ that express in early lymph gland blood cells (hemocytes) and circulating and sessile blood cells, respectively, and incorporates Scer\GAL4Scer\FRT.Rnor\CD2.Act5C to maintain expression in the lymph gland after Scer\GAL4HCH.Hand is down-regulated.)

No wing phenotypes are evident when CTPsynGD4740 is expressed under the control of Scer\GAL4Bx-MS1096.

Knockdown of CTPsyn, through expression of CTPsynGD4740, under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C, does not impede clonal growth.

Expression under the control of Scer\GAL41407 may result in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls (depending on the insertion line used).

Expression under the control of Scer\GAL41407 may result in mild defects in the shape of ganglion mother cells in the larval brain (depending on the insertion line used).

Expression under the control of Scer\GAL41407 may result in an increase in the average size of ganglion mother cells in the larval brain compared to controls (depending on the insertion line used).

Expression under the control of Scer\GAL41407 may result in mild defects in the shape of neuroblasts in the larval brain (depending on the insertion line used).

Adults expressing CTPsynGD4740 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late larval lethality.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Suppressor of
Phenotype Manifest In
Enhanced by
Statement
Reference

CTPsynGD4740, Scer\GAL4CY2 has nucleus | adult stage phenotype, enhanceable by CblF165/Cbl[+]

Enhancer of
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The decrease in percentage of follicle cells undergoing DNA replication (measured by BrdU incorporation) observed in stage 9 egg chambers as well as the decreased follicle cell nuclear size in stage 10A egg chamber expressing CTPsynGD4740 under the control of Scer\GAL4CY2 is further decreased by combination with CblF165 in heterozygous state.

About a fifth of eggs laid by CblF165 heterozygous females expressing CTPsynGD4740 under the control of Scer\GAL4CY2 has a defective collapsed phenotype that is not observed in eggs laid by CblF165/+ flies.

Expression of CTPsynGD4740 enhances the wing hinge phenotype seen when hng1KK103642 is expressed under the control of Scer\GAL4Bx-MS1096.

Knockdown of CTPsyn, through expression of CTPsynGD4740, induces a strong, significant reduction in tumor growth in Ras85DV12.Scer\UAS-scrib1 mutant larval MARCM clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 2 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG6854GD4740
CTPsynGD4740
Name Synonyms
Secondary FlyBase IDs
    References (12)