FlyBase Allele Report: Dmel\SMC3[GD14684]

General Information

Symbol

Dmel\SMC3^GD14684

Species

D. melanogaster

Name

FlyBase ID

FBal0206515

Feature type

allele

Associated gene

Dmel\SMC3

Associated Insertion(s)

Carried in Construct

P{GD14684}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14684}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14684

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

trichogen cell | increased number, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing hair, with Scer\GAL4^ptc-559.1

(Mouri et al., 2012)

Detailed Description

Statement

Reference

Expression of Cap^GD14684 under the control of Scer\GAL4^ptc-559.1 results in wing hair misorientation. Irregular cell size is seen in However, the irregular cell size seen in pupal wings in the domain of Scer\GAL4^ptc-559.1 expression is not suppressed.

(Mouri et al., 2012)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

(Neumüller et al., 2011)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early pupal lethality or late pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 20-30% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in duplication of bristle hairs on the notum in 10-20% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 20-30% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 30-40% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

Expression under the control of Scer\GAL4^pnr-MD237 results in mild thorax closure defects.

Expression under the control of Scer\GAL4^pnr-MD237 results in an enlarged notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14684

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

SMC3^GD14684, Scer\GAL4^ptc-559.1 has abnormal planar polarity phenotype, suppressible | partially by stan^RNAi.UAS.cMa, Scer\GAL4^ptc-559.1

(Mouri et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

SMC3^GD14684, Scer\GAL4^ptc-559.1 has wing hair phenotype, suppressible | partially by stan^RNAi.UAS.cMa, Scer\GAL4^ptc-559.1

(Mouri et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The wing hair misorientation phenotype caused by expression of Cap^GD14684 under the control of Scer\GAL4^ptc-559.1 is partially suppressed by coexpression of stan^{dsRNA.Scer\UAS.cMa}. However, the irregular cell size seen in pupal wings in the domain of Scer\GAL4^ptc-559.1 expression is not suppressed.

(Mouri et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v39205