FB2026_02 , released June 18, 2026
Allele: Dmel\CspGD10571
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General Information
Symbol
Dmel\CspGD10571
Species
D. melanogaster
Name
FlyBase ID
FBal0206696
Feature type
allele
Associated gene
Dmel\Csp
Associated Insertion(s)
Carried in Construct
P{GD10571}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD10571}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD10571
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CspGD10571 under the control of multiple pre- and post-synaptic drivers (Scer\GAL4elav-C155, Scer\GAL4sca.PC and Scer\GAL4C57) has no effect on quantal content compared to wild type controls. Evoked neurotransmission is slightly impaired compared with controls.

      (Brusich et al., 2015)

      Adults expressing CspGD10571 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in flightless flies.

      Expression under the control of Scer\GAL4Mef2.PR results in grossly normal adult indirect flight muscles.

      Expression under the control of Scer\GAL4Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

      Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

      (Schnorrer et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of CspGD10571 completely prevents the compensatory increase in quantal content seen in response to reduced quantal size when GluRIICdsRNA.Scer\UAS.cBa is expressed using multiple pre- and post-synaptic drivers (Scer\GAL4elav-C155, Scer\GAL4sca.PC and Scer\GAL4C57). Evoked neurotransmission is therefore disrupted.

      Expression of CspGD10571 does not prevent the compensatory increase in quantal content seen in response to reduced quantal size when GluRIICdsRNA.Scer\UAS.cBa is expressed under the control of Scer\GAL4C57. Evoked neurotransmission is unaffected.

      (Brusich et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CspGD10571
      (Brusich et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)