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General Information
Symbol
Dmel\DriceGD12284
Species
D. melanogaster
Name
FlyBase ID
FBal0207360
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Drice RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of DriceGD12284 under the control of Scer\GAL4ap-md544 leads to opaque but straight wings, which respectively indicate apoptosis but no growth inhibition during development. Depending on the insertion, additional Dicer-2 expression (for a more efficient RNAi) can induce curled or blistered wings.

Expression under the control of Scer\GAL4C10 does not affect the overall wing size.

Individuals expressing DriceGD12284 under the control of Scer\GAL4ci.PU and subjected to ionizing radiation show a significantly enlarged wing disc anterior compartment, associated with basal cell delamination, as compartment to controls.

Expression of DriceGD12284 under the control of Scer\GAL4ple.PF does not lead to a significant difference in survival or climbing capability as compared to controls under normal conditions; however, these flies exhibit increased resistance to paraquat toxicity, with a significant increase in survival and climbing performance when exposed to paraquat, as compared to control flies exposed to the same treatment.

Adults expressing DriceGD12284 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
NOT Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The dendritic arborization defects observed in class IV dendritic arborizing neurons of nos18/nos53 third instar larvae are suppresed by expression of DriceGD12284 under the control of Scer\GAL4477 in the mutant background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
DriceGD12284
IceGD12284
Name Synonyms
Secondary FlyBase IDs
    References (15)