FlyBase Allele Report: Dmel\Incenp[GD7511]

General Information

Symbol

Dmel\Incenp^GD7511

Species

D. melanogaster

Name

FlyBase ID

FBal0207383

Feature type

allele

Associated gene

Dmel\Incenp

Associated Insertion(s)

Carried in Construct

P{GD7511}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7511}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7511

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

lethal, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in an extreme increase in neuroblast size in the larval brain, without loss of neuroblasts.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of neuroblasts in the larval brain.

(Neumüller et al., 2011)

Adults expressing Incenp^GD7511 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 30-40% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 60-70% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7511

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Incenp^GD7511, Scer\GAL4^ap-md544 is an enhancer of abnormal size | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Incenp^GD7511, Scer\GAL4^ap-md544 is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4^ap-md544, yki^UAS.cHa

(Gerlach et al., 2018)

Other

Statement

Reference

BacA\p35^UAS.cHa, Incenp^GD7511, Scer\GAL4^ap-md544 has centrosome | increased number | third instar larval stage phenotype

(Gerlach et al., 2018)

BacA\p35^UAS.cHa, Incenp^GD7511, Scer\GAL4^ap-md544 has wing disc dorsal compartment | third instar larval stage phenotype

(Gerlach et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Incenp^GD7511 enhances the third instar larval wing disc dorsal compartment enlargement induced by the expression of yki^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts].

(Gerlach et al., 2018)

Xenogenetic Interactions

Statement

Reference

The co-expression of Incenp^GD7511 and BacA\p35^UAS.cHa from the second instar larval stage under the combined control of Scer\GAL4^ap-md544 and Gal80[ts] leads to a significant increase in the average number of centrosomes per cell in the third instar larval wing disc dorsal compartment, as compared to controls.

(Gerlach et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v17044

w¹¹¹⁸; P{GD7511}v17044

Notes on Origin

Discoverer