FlyBase Allele Report: Dmel\PH4αEFB[GD771]

General Information

Symbol

Dmel\PH4αEFB^GD771

Species

D. melanogaster

Name

FlyBase ID

FBal0207978

Feature type

allele

Associated gene

Dmel\PH4αEFB

Associated Insertion(s)

Carried in Construct

P{GD771}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD771}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD771

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates collagen disease

modeled by shi^JF03133

(Zang et al., 2015)

modeled by cact^GL00627

(Zang et al., 2015)

modeled by Tl^10b.UAS

(Zang et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing PH4αEFB^GD771 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PH4αEFB^GD771, Scer\GAL4^r4 is a suppressor of melanotic mass phenotype | larval stage phenotype of Scer\GAL4^r4, shi^NIG.18102R

(Zang et al., 2015)

PH4αEFB^GD771, Scer\GAL4^r4 is a suppressor of melanotic mass phenotype | larval stage phenotype of Scer\GAL4^r4, Tl^10b.UAS

(Zang et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

PH4αEFB^GD771, Scer\GAL4^r4 is a suppressor of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^r4, shi^NIG.18102R

(Zang et al., 2015)

PH4αEFB^GD771, Scer\GAL4^r4 is a suppressor of melanotic mass | larval stage phenotype of Scer\GAL4^r4, Tl^10b.UAS

(Zang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of PH4αEFB^GD771 suppresses the melanotic fat body phenotype caused by expression of shi^NIG.18102R under the control of Scer\GAL4^r4.

Co-expression of PH4αEFB^GD771 suppresses the melanotic phenotype caused by expression of Tl^10b.Scer\UAS under the control of Scer\GAL4^r4.

(Zang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v2464

w¹¹¹⁸; P{GD771}v2464

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

PH4αEFB^GD771

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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