FlyBase Allele Report: Dmel\Prosα6[GD11466]

General Information

Symbol

Dmel\Prosα6^GD11466

Species

D. melanogaster

Name

FlyBase ID

FBal0208141

Feature type

allele

Associated gene

Dmel\Prosα6

Associated Insertion(s)

Carried in Construct

P{GD11466}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11466}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11466

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell shape | larval stage, with Scer\GAL4^He.PZ

(Järvelä-Stölting et al., 2021)

increased cell number | larval stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

lethal, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

melanotic necrosis | larval stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

melanotic necrosis | P-stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

partially lethal, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

short lived, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

some die during P-stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

embryonic/larval hemocyte | increased number | larval stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

embryonic/larval hemocyte | larval stage, with Scer\GAL4^He.PZ

(Järvelä-Stölting et al., 2021)

lamellocyte | increased number | larval stage, with Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^Mef2.PR results in late larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11466

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has increased cell number | larval stage phenotype, non-suppressible by hep^GD1461, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has increased cell number | larval stage phenotype, non-suppressible by Stat92E^GD4492, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has lamellocyte | increased number | larval stage phenotype, suppressible | partially by hep^GD1461, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has lamellocyte | increased number | larval stage phenotype, suppressible | partially by Stat92E^GD4492, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

NOT suppressed by

Statement

Reference

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | increased number | larval stage phenotype, non-suppressible by hep^GD1461, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Prosα6^GD11466, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ has embryonic/larval hemocyte | increased number | larval stage phenotype, non-suppressible by Stat92E^GD4492, Scer\GAL4^He.PZ, Scer\GAL4^Hml.Δ

(Järvelä-Stölting et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v26653

w¹¹¹⁸; P{GD11466}v26653

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11466

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pros35^GD11466

Prosα6^GD11466

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections