FlyBase Allele Report: Dmel\teq[GD4757]

General Information

Symbol

Dmel\teq^GD4757

Species

D. melanogaster

Name

FlyBase ID

FBal0208762

Feature type

allele

Associated gene

Dmel\teq

Associated Insertion(s)

Carried in Construct

P{GD4757}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4757}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4757

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Male and female flies with expression of teq^GD4757 driven by Scer\GAL4^elav.PU or Scer\GAL4^Ilp2.PU (or driven in adulthood only using Scer\GAL4^{elav.Switch.PO} with RU486 feeding) live significantly longer than controls. Male and female flies with expression of teq^GD4757 driven by Scer\GAL4^ppl.PU have a significantly shorter lifespan compared to controls. Male and female flies with expression of teq^GD4757 driven by Scer\GAL4^c739 (or driven in adulthood only using Scer\GAL4^{Mef2.247.Switch} with RU486 feeding) have a lifespan similar to controls.