FlyBase Allele Report: Dmel\ck[GD1408]

General Information

Symbol

Dmel\ck^GD1408

Species

D. melanogaster

Name

FlyBase ID

FBal0209258

Feature type

allele

Associated gene

Dmel\ck

Associated Insertion(s)

Carried in Construct

P{GD1408}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1408}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1408

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Johnston organ | P-stage | somatic clone, with Scer\GAL4^Act.PU

(Li et al., 2016)

male genitalia, with Scer\GAL4^tsh-md621

(Petzoldt et al., 2012)

scolopidium | P-stage | somatic clone, with Scer\GAL4^Act.PU

(Li et al., 2016)

Detailed Description

Statement

Reference

Expression of ck^GD1408 under the control of Scer\GAL4^Act.PU in clones in the Johnston's organ leads to nearly complete detachment of scolopidia from the hinge of the second and third antennal segment.

(Li et al., 2016)

Flies expressing ck^GD1408 under the control of Scer\GAL4^Abd-B-LDN show normal rotation of the male genitalia.

Flies expressing ck^GD1408 under the control of Scer\GAL4^tsh-md621 sometimes show partial rotation of the male genitalia.

(Petzoldt et al., 2012)

Adults expressing ck^GD1408 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1408

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Act.PU, ck^GD1408 has Johnston organ | P-stage | somatic clone phenotype, non-enhanceable | somatic clone by Ubr3^B/Ubr3^B

(Li et al., 2016)

Scer\GAL4^Act.PU, ck^GD1408 has scolopidium | P-stage | somatic clone phenotype, non-enhanceable | somatic clone by Ubr3^B/Ubr3^B

(Li et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Flies carrying Ubr3^B mutant clones expressing (under the Scer\GAL4^Act.PU driver) ck^GD1408 in the Johnston's organ display nearly complete detachment of scolopidia from the hinge of the second and third antennal segment - similar to animals with clones expressing the ck^GD1408 alone.

(Li et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v9265

w¹¹¹⁸; P{GD1408}v9265

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1408

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ck^GD1408

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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