FlyBase Allele Report: Dmel\msl-2[GD14745]

General Information

Symbol

Dmel\msl-2^GD14745

Species

D. melanogaster

Name

FlyBase ID

FBal0210112

Feature type

allele

Associated gene

Dmel\msl-2

Associated Insertion(s)

Carried in Construct

P{GD14745}

Also Known As

UAS-msl-2^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14745}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14745

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

abnormal size | adult stage | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Phenotype Manifest In

eye | male limited, with Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Detailed Description

Statement

Reference

The expression of msl-2^GD14745 under the control of Scer\GAL4^ey.PH leads to smaller eyes in males, but not in females, as compared to controls.

(Clemente-Ruiz et al., 2016)

Adults expressing msl-2^GD14745 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in a weak flyer phenotype.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14745

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

msl-2^GD14745, Scer\GAL4^ey.PH is an enhancer | female of abnormal size | adult stage phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

msl-2^GD14745, Scer\GAL4^ey.PH is an enhancer | female of visible phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

msl-2^GD14745, Scer\GAL4^ey.PH is an enhancer | female of eye phenotype of Bub3^GD9924, Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

msl-2^GD14745 is rescued by msl-2^UAS.cUa/Scer\GAL4^ey.PH

(Clemente-Ruiz et al., 2016)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v29356

w¹¹¹⁸; P{GD14745}v29356

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14745

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

msl-2^GD14745

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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