FlyBase Allele Report: Dmel\robo1[GD14414]

General Information

Symbol

Dmel\robo1^GD14414

Species

D. melanogaster

Name

FlyBase ID

FBal0210482

Feature type

allele

Associated gene

Dmel\robo1

Associated Insertion(s)

Carried in Construct

P{GD14414}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14414}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14414

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing robo1^GD14414 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 40-50% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 0% or 10-20% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 60-70% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14414

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^wor.PA, robo1^GD14414 has increased cell number | somatic clone phenotype, suppressible by fra^GD68/Scer\GAL4^wor.PA

(de Torres-Jurado et al., 2022)

Suppressor of

Statement

Reference

Scer\GAL4^wor.PA/robo1^GD14414 is a suppressor of increased cell number | somatic clone phenotype of Scer\GAL4^wor.PA, fra^GD68

(de Torres-Jurado et al., 2022)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^wor.PA, robo1^GD14414 has neuroblast | increased number | somatic clone phenotype, suppressible by fra^GD68/Scer\GAL4^wor.PA

(de Torres-Jurado et al., 2022)

Suppressor of

Statement

Reference

Scer\GAL4^wor.PA/robo1^GD14414 is a suppressor of neuroblast | increased number | somatic clone phenotype of Scer\GAL4^wor.PA, fra^GD68

(de Torres-Jurado et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14414

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

robo1^GD14414

robo^GD14414

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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