FlyBase Allele Report: Dmel\tll[GD1548]

General Information

Symbol

Dmel\tll^GD1548

Species

D. melanogaster

Name

FlyBase ID

FBal0210769

Feature type

allele

Associated gene

Dmel\tll

Associated Insertion(s)

Carried in Construct

P{GD1548}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1548}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1548

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | larval stage, with Scer\GAL4^neur-P72

(Apitz and Salecker, 2015)

abnormal developmental rate | larval stage | nutrition conditional, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

abnormal starvation stress response | adult stage, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

abnormal starvation stress response | adult stage, with Scer\GAL4^NP0001

(Havula et al., 2022)

abnormal starvation stress response | adult stage | nutrition conditional, with Scer\GAL4^Mef2.PU

(Havula et al., 2022)

decreased body weight | adult stage, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

lethal - all die before end of P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

majority die during P-stage | nutrition conditional, with Scer\GAL4^Ubi.PU

(Havula et al., 2022)

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Ubi.PU

(Havula et al., 2022)

short lived | :calorie restriction conditional | nutrition conditional, with Scer\GAL4^Mef2.PU

(Havula et al., 2022)

short lived | calorie restriction conditional, with Scer\GAL4^Cg.PU

(Havula et al., 2022)

short lived | calorie restriction conditional, with Scer\GAL4^NP0001

(Havula et al., 2022)

some die during larval stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

some die during P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

adult optic lobe neuron, with Scer\GAL4^neur-P72

(Apitz and Salecker, 2015)

larval inner optic anlage, with Scer\GAL4^neur-P72

(Apitz and Salecker, 2015)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

The expression of tll^GD1548 under the control of Scer\GAL4^Cg.PU induces a delay in pupation in a high sugar diet.

Adults expressing tll^GD1548 under the control of Scer\GAL4^NP0001 show decreased survival to starvation when reared under high sugar diet.

(Havula et al., 2022)

Expression of tll^GD1548 in the distal inner proliferation center (d-IPC) under the control of Scer\GAL4^neur-P72 results in an increased number of dpn ase-positive neuroblasts compared with controls. The number of ato and dac neuroblasts and lobular plate neurons is severely reduced.

(Apitz and Salecker, 2015)

Expression of tll^GD1548 under the control of Scer\GAL4^Bx-MS1096 has no effect on male wing size or patterning.

Expression of tll^GD1548 under the control of Scer\GAL4^Bx-MS1096 has no effect on female wing size or patterning.

(Schertel et al., 2015)

Adults expressing tll^GD1548 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 60-70% of the Scer\GAL4^pnr-MD237 expression domain.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1548

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v6236

w¹¹¹⁸; P{GD1548}v6236

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1548

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tll^GD1548

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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