FlyBase Allele Report: Dmel\trc[S292A.UAS.L]

General Information

Symbol

Dmel\trc^S292A.UAS.L

Species

D. melanogaster

Name

FlyBase ID

FBal0215623

Feature type

allele

Associated gene

Dmel\trc

Associated Insertion(s)

Carried in Construct

P{UAS-trc.L.S292A}

Key Links

Transgenic product class

missense_variant

(He et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(He et al., 2005)

Mutagen

in vitro construct

(He et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-trc.L.S292A}

Cytology

Description

Amino acid replacement: S292A.

(He et al., 2005)

UASt regulatory sequences drive expression of a mutated form of the long isoform of trc with the above amino acid substitution.

(He et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

trc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

macrochaeta, with Scer\GAL4^ap-md544

(He et al., 2005)

macrochaeta, with Scer\GAL4^neur-P72

(He et al., 2005)

wing hair | increased number, with Scer\GAL4^ap-md544

(He et al., 2005)

wing hair | increased number, with Scer\GAL4^ap-md544, trc^S066917a

(He et al., 2005)

Detailed Description

Statement

Reference

Expression of trc^{S292A.Scer\UAS} under the control of Scer\GAL4^ap-md544 results in a multiple wing hair phenotype. On average, 1.5-4 hairs per cell are produced but many cells still produce a single hair. Expression of trc^{S292A.Scer\UAS} in the notum, driven by either Scer\GAL4^ap-md544 or Scer\GAL4^neur-P72 results in split or branched bristles, particularly on the abdomen, and in deformed bristles that are short, fat, bent, and twisted.

Expression of trc^{S292A.Scer\UAS} under the control of Scer\GAL4^ap-md544 in a trc^S066917a/+ background enhances the multiple wing hair phenotype seen when trc^S066917a is expressed in a wild-type background.

(He et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, trc^S292A.UAS.L has wing hair | increased number phenotype, enhanceable by fry¹/fry[+]

(He et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

A fry¹/+ background enhances the multiple wing hair phenotype of flies that express trc^{S292A.Scer\UAS} under the control of Scer\GAL4^ap-md544.

(He et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

trc^S292A.UAS.L/Scer\GAL4^Act5C.PI fails to rescue trc^S066917a

(He et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32084

w^*; P{UAS-trc.L.S292A}2

32087

w^*; P{UAS-trc.L.S292A}3/TM3, st³⁴ Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

trc^{S292A.Scer\UAS.L}

trc^{S292A.Scer\UAS}

trc^S292A.UAS.L

trc^S292A

(He et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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