FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trcT453E.UAS.L
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General Information
Symbol
Dmel\trcT453E.UAS.L
Species
D. melanogaster
Name
FlyBase ID
FBal0215627
Feature type
allele
Associated gene
Dmel\trc
Associated Insertion(s)
Carried in Construct
P{UAS-trc.L.T453E}
Key Links
Transgenic product class
missense_variant
(He et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(He et al., 2005)
Mutagen
in vitro construct
(He et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-trc.L.T453E}
Cytology
Description

Amino acid replacement: T453E.

(He et al., 2005)

UASt regulatory sequences drive expression of a mutated form of the long isoform of trc with the above amino acid substitution.

(He et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
trc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1RNAi.UAS.cYa
      (Wu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of trcT453E.Scer\UAS partially suppresses the number of dendrite-dendrite crossings seen in rawjj102 mutant class IV arborizing neuron clones.

      (Lee et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of trcT453E.Scer\UAS under the control of Scer\GAL4109(2)80 partially suppresses the number of dendrite-dendrite crossings seen in rawjj102 mutant class IV dendritic arborizing neuron clones.

      (Lee et al., 2015)

      Co-expression of trcT453E.Scer\UAS suppresses the defects in flight ability caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW.

      The abnormal wing posture phenotype seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is suppressed by co-expression of trcT453E.Scer\UAS.

      (Wu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      FlyBase curator comment: In FBrf0227069 the mutation in this transgene is referred to as T449E. T449 is the equivalent of T453 in the short isoform of trc. This line has been made using the long isoform so is named accordingly.

      (Lee et al., 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      trcS292E
      (He et al., 2005)
      trcT453E.Scer\UAS.L
      trcT453E.Scer\UAS
      trcT453E.UAS.L
      Name Synonyms
      Secondary FlyBase IDs
        References (3)