FlyBase Allele Report: Dmel\rumi[44]

General Information

Symbol

Dmel\rumi⁴⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0216682

Feature type

allele

Associated gene

Dmel\rumi

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

In-frame deletion and missense mutation (A85Q).

(Acar et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | third instar larval stage | conditional

(Matsumoto et al., 2016)

visible

(Acar et al., 2008)

visible | recessive | heat sensitive

(Acar et al., 2008)

visible | recessive | somatic clone

(Acar et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

rumi⁴⁴ homozygous third instar larval wing discs exhibit an increased number of supraalar neurons when individuals are raised at 30[o]C, but not at 25[o]C, of temperature, as compared to controls.

(Matsumoto et al., 2016)

rumi⁴⁴ homozygous wing disc clones exhibit an increase in the number of sensory organ precursors at 30[o]C, but display wild-type numbers at 18 and 25[o]C.

(Ishio et al., 2015)

Homozygous clones in the adult intestine are indistinguishable from wild-type clones at 18[o]C. However, at 21 and 22[o]C, the number of intestinal stem cell (ISC)-like cells is increased, while the ratio of differentiated enteroendocrine cells to enterocytes is unaffected. At 25 and 28[o}C, a large increase in the number of ISC-like cells is seen and the ratio of enteroendocrine cells to enterocytes is increased compared to wild type. At 28[o]C, large polyploid enterocytes are no longer seen.

(Perdigoto et al., 2011)

Loss of rumi in random rumi⁴⁴ wing clones results in the thickening of wing veins and 'notches' of tissue loss in the wing margin.

(Takeuchi et al., 2011)

Homozygous clones in the adult thorax show loss of some bristles at 25^oC. However, at 18^oC, homozygous clones do not show bristle loss, but instead show an increase in bristle density.

Some rumi⁴⁴ hemizygotes reach adulthood at 25^oC. These animals show a severe loss of microchaetae. However, rumi⁴⁴ hemizygotes raised at 18^oC do not show bristle loss.

Homozygotes raised at 18^oC show a mild Delta phenotype in the wing.

(Acar et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

rumi⁴⁴ has visible | recessive phenotype, enhanceable by N[+]/N^55e11

(Acar et al., 2008)

rumi⁴⁴ has visible phenotype, enhanceable by Delta^9P/Dl[+]

(Acar et al., 2008)

Suppressed by

Statement

Reference

rumi⁴⁴ has visible | recessive | heat sensitive phenotype, suppressible by Dp(1;2)51b/+

(Acar et al., 2008)

Enhancer of

Statement

Reference

rumi⁴⁴/rumi⁴⁴ is an enhancer of increased cell number | third instar larval stage | conditional phenotype of Ofut1^R245AKI

(Matsumoto et al., 2016)

rumi⁴⁴/rumi⁴⁴ is an enhancer of visible | dominant phenotype of Delta^9P

(Acar et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

rumi⁴⁴ has sensory mother cell | somatic clone | heat sensitive phenotype, enhanceable by Ofut1^R245AKI

(Ishio et al., 2015)

rumi⁴⁴ has microchaeta phenotype, enhanceable by N[+]/N^55e11

(Acar et al., 2008)

rumi⁴⁴ has wing vein phenotype, enhanceable by Delta^9P/Dl[+]

(Acar et al., 2008)

Suppressed by

Statement

Reference

rumi⁴⁴ has wing vein | somatic clone | heat sensitive phenotype, suppressible by Hsap\POGLUT1^UAS.Tag:FLAG/Scer\GAL4^c684

(Takeuchi et al., 2011)

rumi⁴⁴ has wing margin | somatic clone | heat sensitive phenotype, suppressible by Hsap\POGLUT1^UAS.Tag:FLAG/Scer\GAL4^c684

(Takeuchi et al., 2011)

rumi⁴⁴ has microchaeta | heat sensitive phenotype, suppressible by Dp(1;2)51b/+

(Acar et al., 2008)

NOT suppressed by

Statement

Reference

rumi⁴⁴ has wing vein | somatic clone | heat sensitive phenotype, non-suppressible by Scer\GAL4^c684/Hsap\POGLUT2^UAS.Tag:FLAG

(Takeuchi et al., 2011)

rumi⁴⁴ has wing margin | somatic clone | heat sensitive phenotype, non-suppressible by Scer\GAL4^c684/Hsap\POGLUT2^UAS.Tag:FLAG

(Takeuchi et al., 2011)

rumi⁴⁴ has wing vein | somatic clone | heat sensitive phenotype, non-suppressible by Hsap\POGLUT3^UAS.Tag:FLAG/Scer\GAL4^c684

(Takeuchi et al., 2011)

rumi⁴⁴ has wing margin | somatic clone | heat sensitive phenotype, non-suppressible by Hsap\POGLUT3^UAS.Tag:FLAG/Scer\GAL4^c684

(Takeuchi et al., 2011)

Enhancer of

Statement

Reference

rumi⁴⁴/rumi⁴⁴ is an enhancer of wing disc | third instar larval stage phenotype of Ofut1^R245AKI

(Matsumoto et al., 2016)

rumi⁴⁴/rumi⁴⁴ is an enhancer of eo neuron | third instar larval stage | conditional phenotype of Ofut1^R245AKI

(Matsumoto et al., 2016)

rumi⁴⁴ is an enhancer of sensory mother cell | somatic clone | heat sensitive phenotype of Ofut1^R245AKI

(Ishio et al., 2015)

rumi⁴⁴/rumi⁴⁴ is an enhancer of wing vein phenotype of Delta^9P

(Acar et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

rumi⁴⁴ homozygosity strongly enhances the increased number of supraalar neurons present in the third instar larval wing discs of O-fut1^R245AKI homozygotes raised at 25[o]C of temperature.

(Matsumoto et al., 2016)

O-fut1^R245AKI and rumi⁴⁴ homozygous double mutant wing disc clones exhibit an increase in the number of sensory organ precursors at 18, 25 and 30[o]C.

(Ishio et al., 2015)

Adding Dp(1;2)51b restores most microchaetae in rumi⁴⁴ hemizygotes raised at 25^oC.

rumi⁴⁴ hemizygotes raised at 18^oC and also carrying N^55e11/+ show loss of microchaetae.

Flies that are homozygous for rumi⁴⁴ and heterozygous for Dl^9P show a synergistic increase in wing vein expansion.

(Acar et al., 2008)

Xenogenetic Interactions

Statement

Reference

Overexpression of Hsap\POGLUT1^{Scer\UAS.T:Zzzz\FLAG} suppresses the wing phenotypes found in rumi⁴⁴ wing mutant clones.

Overexpression of Hsap\KDELC1^{Scer\UAS.T:Zzzz\FLAG} or Hsap\KDELC2^{Scer\UAS.T:Zzzz\FLAG} fails to suppress the wing phenotypes found in rumi⁴⁴ wing mutant clones.

(Takeuchi et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

78568

y¹ w^*; P{neoFRT}82B rumi⁴⁴/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rumi⁴⁴

(Matsumoto et al., 2016, Ishio et al., 2015, Perdigoto et al., 2011, Takeuchi et al., 2011, Ishikawa et al., 2010, Acar et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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