FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\prom2
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General Information
Symbol
Dmel\prom2
Species
D. melanogaster
Name
FlyBase ID
FBal0216788
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
eyc1
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Lesion in the prom gene.

    Mutation affects the donor site.

    Nucleotide substitution: G1226A.

    A to G transition 162bp downstream of the CG42383 stop codon and a single base pair deletion 486bp downstream of the CG42383 stop codon (it remains possible that these nucleotide changes are polymorphisms as the parental chromosome is not available for comparison).

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The external morphology of the eye is indistinguishable from wild type in mutant animals. Mutant rhabdomeres are fragmented and rhabdomeres are joined to each other and to stalks of other photoreceptors by inappropriate adhesions. prom2 photoreceptors are indistinguishable from wild type at 37% pupal development (p.d.). The mutant phenotype is clearly seen by 55% p.d. The inter-rhabdomeral space fails to open and photoreceptor cells contact each other in both rhabdomere tip-to-tip and rhabdomere-to-stalk contacts. Distinctive stalk and rhabdomere membranes are evident, but they are irregularly ordered. Loops of stalk membrane are trapped by abnormal adhesions. Contacts between photoreceptor cells seen in adult ommatidia commonly include those seen during rhabdomere extension; the rhabdomere of R4 often bifurcates to contact R2 and R7. In addition, strong R5/R6 contact (not seen during extension) is also common in mutant adults.

    The external morphology of the eye is indistinguishable from wild type in mutant animals. Mutant rhabdomeres are fragmented and rhabdomeres are joined to each other and to stalks of other photoreceptors by inappropriate adhesions. eyc1 photoreceptors are indistinguishable from wild type at 37% pupal development (p.d.). The mutant phenotype is clearly seen by 55% p.d. The inter-rhabdomeral space fails to open and photoreceptor cells contact each other in both rhabdomere tip-to-tip and rhabdomere-to-stalk contacts. Distinctive stalk and rhabdomere membranes are evident, but they are irregularly ordered. Loops of stalk membrane are trapped by abnormal adhesions. Contacts between photoreceptor cells seen in adult ommatidia commonly include those seen during rhabdomere extension; the rhabdomere of R4 often bifurcates to contact R2 and R7. In addition, strong R5/R6 contact (not seen during extension) is also common in mutant adults.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Separable from: Actn4.

    Comments
    Comments

    FlyBase curator comment: The prom2 allele was previously referred to as "eyc2" in FlyBase due to confusion over which transcription unit corresponds to the "eyc" complementation group. However, FBrf0198649 shows that the lesion in the mutant maps within the prom transcription unit, and thus the allele is now listed as an allele of prom in FlyBase.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
    • FBal0137261
    • FBal0193681
    References (7)