FlyBase Allele Report: Dmel\Duox[K]

General Information

Symbol

Dmel\Duox^K

Species

D. melanogaster

Name

FlyBase ID

FBal0219680

Feature type

allele

Associated gene

Dmel\Duox

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

neomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Hurd et al., 2015)

neomorphic allele - genetic evidence

(Hurd et al., 2015)

Mutagen

ethyl methanesulfonate

(Cook, 2008.12.1)

Progenitor genotype

Cytology

Description

(Amino acid change is revision of data in FBrf0230212).

(Erdi, 2020.4.4)

Amino acid replacement: G1505S.

(Erdi, 2020.4.4)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,816,443..2,816,443 [-]

Nucleotide change:

G2816443A

Amino acid change:

G1505S | Duox-PB; G1505S | Duox-PC

Reported amino acid change:

G1505S

Reported_genomic_loc:

2L_r6:2816443..2816443

Comment:

The nucleotide change is correct and the amino acid change is reversed between Duox[Cy] and Duox[K] in Figure 1B.

(Hurd et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Duox^Cy)

(Hurd et al., 2015)

lethal (with Duox^KG07745)

(Hurd et al., 2015)

lethal | recessive

(Hurd et al., 2015)

visible | dominant

(Hurd et al., 2015)

Phenotype Manifest In

wing

(Hurd et al., 2015)

Detailed Description

Statement

Reference

Reduction in dietary niacinamide causes a dose-dependent decrease in the expressivity of the 'Curly' wing phenotype (upward curvature of the wing) seen in Cy^K heterozygotes.

(Hurd et al., 2015)

Cy^K has a dominant phenotype similar to Cy¹.

(Cook, 2008.12.1)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Duox^K has visible | dominant phenotype, suppressible by Scer\GAL4^ap.PU/Nadk1a^KK106577

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, suppressible by cysu^GD6190/Scer\GAL4^ap.PU

(Hurd et al., 2015)

NOT suppressed by

Statement

Reference

Duox^K has visible | dominant phenotype, non-suppressible by Pxn^KK108816/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Pxn^GD5987/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by CG10211^GD5320/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxt^GD6192

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxt^KK103684

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by cd^GD3115/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/CG42331^GD12065

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by CG42331^KK110316/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/CG42331^KK105949

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxd^GD16228

(Hurd et al., 2015)

Duox^K has visible | dominant phenotype, non-suppressible by Scer\GAL4^ap.PU/Irc^KK106899

(Hurd et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Duox^K has wing phenotype, suppressible by Scer\GAL4^ap.PU/Nadk1a^KK106577

(Hurd et al., 2015)

Duox^K has wing phenotype, suppressible by cysu^GD6190/Scer\GAL4^ap.PU

(Hurd et al., 2015)

NOT suppressed by

Statement

Reference

Duox^K has wing phenotype, non-suppressible by Pxn^KK108816/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Pxn^GD5987/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/Irc^KK106899

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by CG10211^GD5320/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxt^GD6192

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxt^KK103684

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by cd^GD3115/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/CG42331^GD12065

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by CG42331^KK110316/Scer\GAL4^ap.PU

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/CG42331^KK105949

(Hurd et al., 2015)

Duox^K has wing phenotype, non-suppressible by Scer\GAL4^ap.PU/Pxd^GD16228

(Hurd et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of CG6145^KK106577 under the control of Scer\GAL4^ap.PU suppresses the 'Curly' wing phenotype (upward curvature of the wing) seen in Cy^K heterozygotes.

The 'Curly' wing phenotype (upward curvature of the wing) of Cy^K heterozygotes is not suppressed by expression under the control of Scer\GAL4^ap.PU by any one of Pxn^KK108816, Pxn^GD5987, CG10211^GD5320, Pxt^GD6192, Pxt^KK103684, cd^GD3115, CG42331^GD12065, CG42331^KK110316, CG42331^KK105949, Pxd^GD16228 or Irc^KK106899.

Expression of cysu^GD6190 under the control of Scer\GAL4^ap.PU fully suppresses the 'Curly' wing phenotype (upward curvature of the wing) of Cy^K heterozygotes.

(Hurd et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Duox^Cy

(Cook, 2008.12.1)

Comments

Expression of Cy^{Scer\UAS.P\T.cHa} under the control of Scer\GAL4^Act5C.PI rescues the lethality of Cy^K homozygotes, but does not rescue the 'Curly' wing phenotype (upward curvature of the wing) of Cy^K heterozygotes.

(Hurd et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26167

Duox^K/In(2LR)Gla, wg^Gla-1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cy^K

(Hurd et al., 2015, Cook, 2008.12.1)

Duox^K

DuoxK

(Erdi, 2020.4.4)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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