FlyBase Allele Report: Dmel\cic[Q474X]

General Information

Symbol

Dmel\cic^Q474X

Species

D. melanogaster

Name

FlyBase ID

FBal0220445

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q474X.

(Tseng et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:20,295,126..20,295,126 [+]

Nucleotide change:

C20295126T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

Q474term

(Tseng et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

embryonic/larval segmentation phenotype | maternal effect (with cic¹)

(Forés et al., 2017)

increased cell number | somatic clone

(Tseng et al., 2007)

lethal

(Rodríguez-Muñoz et al., 2022, Tseng et al., 2007)

visible (with cic⁴)

(Forés et al., 2017)

visible | somatic clone

(Tseng et al., 2007)

Phenotype Manifest In

embryonic/first instar larval cuticle (with cic¹)

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic¹), with cic^L.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic¹), with cic^L-N2.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic¹), with cic^{LYLmut.Tag:HA}

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic¹), with cic^Smut.Tag:HA

(Forés et al., 2015)

embryonic/first instar larval cuticle (with cic¹), with cic^ΔN2.Tag:HA

(Forés et al., 2015)

eye | somatic clone

(Tseng et al., 2007)

ommatidium | somatic clone

(Tseng et al., 2007)

wing (with cic⁴)

(Forés et al., 2017)

wing disc | somatic clone

(Tseng et al., 2007)

wing vein (with cic⁴)

(Forés et al., 2017)

Detailed Description

Statement

Reference

cic⁴/cic^Q474X adults exhibit wing defects including reduced wing size and ectopic wing vein material in the wings.

Embryos produced by cic¹/cic^Q474X females exhibit severe defects including loss of thoracic and abdominal regions.

(Forés et al., 2017)

Homozygous clones in the eye result in over-representation of mutant tissue over wild-type tissue in the eye. Eyes containing homozygous clones consistently contain more ommatidia than normal and are thus slightly larger than normal. Mutant ommatidia in the adult retina are indistinguishable from wild-type in terms of the size, number and arrangement of photoreceptor cells.

Mutant cells from mosaic wing discs of early third instar larvae have a similar DNA content profile and cell size as wild-type cells when analysed by flow cytometry. The mutant clones occupy a larger area of the larval wings disc and typically contain more cells than their wild-type twin spots.

(Tseng et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

cic^Q474X, puc^E69/puc[+] has partially lethal - majority die | dominant phenotype

(Beam and Moberg, 2010)

Phenotype Manifest In

Other

Statement

Reference

Ras85D^ΔC40B, cic^Q474X has ommatidium | somatic clone phenotype

(Tseng et al., 2007)

Ras85D^ΔC40B, cic^Q474X has photoreceptor neuron | somatic clone phenotype

(Tseng et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Ras85D^ΔC40B, cic^Q474X double mutant clones in the eye disc are typically larger than their wild-type twin spots, as occurs in cic^Q474X single mutant clones. In the adult, double mutant clones are seen, but the mutant tissue lacks the normal ommatidial architecture.

(Tseng et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cic^fet-E11

(Tseng et al., 2007)

cic^fet-U6

(Tseng et al., 2007)

Partially rescued by

cic^Q474X/cic¹ is partially rescued by cic^Smut.Tag:HA

(Forés et al., 2015)

cic^Q474X/cic¹ is partially rescued by cic^L-N2.Tag:HA

(Forés et al., 2015)

Not rescued by

cic^Q474X/cic¹ is not rescued by cic^L.Tag:HA

(Forés et al., 2015)

cic^Q474X/cic¹ is not rescued by cic^ΔN2.Tag:HA

(Forés et al., 2015)

cic^Q474X/cic¹ is not rescued by cic^{LYLmut.Tag:HA}

(Forés et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cic^Q474X

(Rodríguez-Muñoz et al., 2022, Newcomb et al., 2018, Papagianni et al., 2018, Forés et al., 2017, Pascual et al., 2017, Suisse et al., 2017, Forés et al., 2015, Andreu et al., 2012, Hafezi et al., 2012, Ajuria et al., 2011, Beam and Moberg, 2010, Tseng et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close