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General Information
Symbol
Dmel\cicQ474X
Species
D. melanogaster
Name
FlyBase ID
FBal0220445
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C20295126T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q474term | cic-PA; Q474term | cic-PB; Q474term | cic-PC; Q1212term | cic-PD; Q1216term | cic-PG; Q322term | cic-PH

    Reported amino acid change:

    Q474term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: Q474X.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    cic4/cicQ474X adults exhibit wing defects including reduced wing size and ectopic wing vein material in the wings.

    Embryos produced by cic1/cicQ474X females exhibit severe defects including loss of thoracic and abdominal regions.

    Homozygous clones in the eye result in over-representation of mutant tissue over wild-type tissue in the eye. Eyes containing homozygous clones consistently contain more ommatidia than normal and are thus slightly larger than normal. Mutant ommatidia in the adult retina are indistinguishable from wild-type in terms of the size, number and arrangement of photoreceptor cells.

    Mutant cells from mosaic wing discs of early third instar larvae have a similar DNA content profile and cell size as wild-type cells when analysed by flow cytometry. The mutant clones occupy a larger area of the larval wings disc and typically contain more cells than their wild-type twin spots.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Other
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Ras85DΔC40B, cicQ474X double mutant clones in the eye disc are typically larger than their wild-type twin spots, as occurs in cicQ474X single mutant clones. In the adult, double mutant clones are seen, but the mutant tissue lacks the normal ommatidial architecture.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    References (11)