FB2026_02 , released June 18, 2026
Allele: Dmel\cic4
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General Information
Symbol
Dmel\cic4
Species
D. melanogaster
Name
FlyBase ID
FBal0326590
Feature type
allele
Associated gene
Dmel\cic
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Forés et al., 2017)
Mutagen
CRISPR/Cas9
(Forés et al., 2017)
Progenitor genotype
Cytology
Description

12bp deletion that removes 4 amino acid residues (RQKL) from the cic C1 domain, 3 of which are highly conserved residues from the C1 core.

(Forés et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:20,300,276..20,300,287 [+]
Comment:

12bp deletion that removes 4 amino acid residues (RQKL) from the cic C1 domain of cic.

(Forés et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cic4/cic4 flies are semi-lethal and show a range of developmental defects. Surviving adults exhibit thickened wing veins and ectopic vein material in the wings. cic4/cic4 males are sterile and exhibit a severe genitalia rotation phenotype. Embryos produced by cic4/cic4 females lack all central thoracic and abdominal segmented regions.

      cic4/cicQ474X and cic4/Df(3R)ED6027 adults exhibit wing defects including reduced wing size and ectopic wing vein material in the wings.

      Embryos produced by cic1/cic4 females exhibit severe defects including loss of thoracic and abdominal regions.

      (Forés et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cic4
      (Rodríguez-Muñoz et al., 2022, Papagianni et al., 2018, Forés et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)