FlyBase Allele Report: Dmel\cic[fet-E11]

General Information

Symbol

Dmel\cic^fet-E11

Species

D. melanogaster

Name

FlyBase ID

FBal0130458

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

P{}cic^fet-E11

Carried in Construct

Also Known As

cic^fetE11

Key Links

Allele class

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Goff et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{}cic^fet-E11

Cytology

Description

Insertion of a P-element in 3' to 5' orientation after nucleotide 6510 in exon 10, introducing an in-frame stop codon that is predicted to produce a truncated protein lacking the conserved C-terminal domain.

(Goff et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | adult stage (with cic^fet-T6)

(Jin et al., 2015)

increased occurrence of cell division | adult stage (with cic^fet-U6)

(Jin et al., 2015)

lethal | embryonic stage | germline clone | maternal effect | recessive

(Goff et al., 2001)

lethal - all die during embryonic stage | maternal effect (with cic^fet-U6)

(Goff et al., 2001)

some die during embryonic stage | maternal effect (with cic^fet-U6)

(Goff et al., 2001)

some die during embryonic stage | maternal effect | recessive | somatic clone

(Goff et al., 2001)

terminal phenotype | embryonic stage | germline clone | maternal effect | recessive

(Goff et al., 2001)

viable

(Goff et al., 2001)

viable (with cic^fet-T6)

(Goff et al., 2001)

viable (with cic^fet-U6)

(Goff et al., 2001)

visible (with cic^fet-T6)

(Goff et al., 2001)

visible (with cic^fet-U6)

(Goff et al., 2001)

Phenotype Manifest In

adult midgut (with cic^fet-T6)

(Jin et al., 2015)

adult midgut (with cic^fet-U6)

(Jin et al., 2015)

dorsal appendage (with cic^fet-U6)

(Atkey et al., 2006, Goff et al., 2001)

egg (with cic^fet-U6)

(Atkey et al., 2006)

egg chorion (with cic^fet-T6)

(Goff et al., 2001)

egg chorion (with cic^fet-U6)

(Goff et al., 2001)

embryonic/first instar larval cuticle (with cic^fet-T6)

(Goff et al., 2001)

embryonic epidermis (with cic^fet-U6)

(Goff et al., 2001)

intestinal stem cell | adult stage (with cic^fet-T6)

(Jin et al., 2015)

intestinal stem cell | adult stage (with cic^fet-U6)

(Jin et al., 2015)

wing (with cic^fet-T6)

(Goff et al., 2001)

wing (with cic^fet-U6)

(Goff et al., 2001)

wing vein (with cic^fet-U6)

(Goff et al., 2001)

Detailed Description

Statement

Reference

Number of mitotic cells per midgut in cic^fet-E11 heterozygote adults is not significantly changed compared to wild-type but it is significantly increased both in cic^fet-U6/cic^fet-E11 and cic^fet-T6/cic^fet-E11 transheterozygotes.

(Jin et al., 2015)

Approximately 12.9% of cic^fet-E11/cic^fet-U6 females exhibit a weak eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally with a trace of ventral collar material. The dorsalmost region remains free of appendage material.

Approximately 19.3% of cic^fet-U6/cic^fet-E11 females exhibit a moderate eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a ventral collar of ectopic appendage-like material. The dorsalmost region remains free of appendage material.

Approximately 30.0% of cic^fet-U6/cic^fet-E11 exhibit a moderate-severe eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a pronounced ventral collar of ectopic appendage-like material. The dorsalmost region remains free of appendage material.

(Atkey et al., 2006)

Eggs derived from cic^fet-U6/cic^fet-E11 females are dorsalised. The eggs are shorter than normal and have broader dorsal appendages that are shifted laterally, with appendage base material encircling the entire anterior circumference of the egg. Embryos derived from cic^fet-U6/cic^fet-E11 females fail to hatch and are dorsalised (the secreted cuticle consists entirely of dorsal epidermis). cic^fet-U6/cic^fet-E11 adults have smaller wings than normal, with vein thickening and blistering. Eggs produced by females with homozygous germline clones are wild-type in appearance (not dorsalised), but 100% of the embryos derived from these eggs fail to hatch. The cuticle has normal dorso-ventral polarity, but shows expansion of the termini at the expense of segmentation (resembling a tor gain-of-function phenotype). Eggs derived from females carrying homozygous follicle cell clones are wild-type in appearance (not dorsalised). 13% of the embryos derived from these females fail to hatch (of these, 10% are locally dorsalised along the anterior-posterior axis and 1% are completely dorsalised), and 87% hatch. cic^fet-T6/cic^fet-E11 females lay eggs with a dorsalised eggshell and embryo.

(Goff et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cic[+]/cic^fet-E11 is a suppressor | partially of lethal | dominant | maternal effect | embryonic stage phenotype of spz^D1

(Goff et al., 2001)

Phenotype Manifest In

Suppressed by

Statement

Reference

cic^fet-U6/cic^fet-E11 has dorsal appendage phenotype, suppressible by mirr^6D1

(Atkey et al., 2006)

cic^fet-U6/cic^fet-E11 has egg phenotype, suppressible by mirr^6D1

(Atkey et al., 2006)

Other

Statement

Reference

Egfr^t1, cic^fet-T6/cic^fet-E11 has embryonic/first instar larval cuticle phenotype

(Goff et al., 2001)

Egfr^t1, cic^fet-T6/cic^fet-E11 has egg chorion phenotype

(Goff et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 34.4% of cic^fet-E11/mirr^6D1 cic^fet-U6 females exhibit a weak eggshell phenotype. Approximately 37.4% of cic^fet-U6/mirr^6D1 cic^fet-E11 females exhibit a weak-moderate eggshell phenotype. Approximately 24.5% of cic^fet-U6/mirr^6D1 cic^fet-E11 females exhibit a moderate eggshell phenotype. Approximately 37.9% of cic^fet-U6/mirr^6D1 cic^fet-E11 females exhibit a moderate-severe eggshell phenotype. The dorsal midline is expanded and the appendages are broader and positioned laterally and exhibit a thick ventral collar of ectopic appendage-like material. The dorsalmost region remains free of appendage material. There is an increase in the weak phenotype, and a decrease in the severe phenotype compared to the cic^fet-E11/cic^fet-U6 mutant, indicating that mirr^6D1 suppresses the cic^fet-E11/cic^fet-U6 phenotype.

(Atkey et al., 2006)

Egfr^t1/Egfr^t1 ; cic^fet-T6/cic^fet-E11 females lay eggs with a dorsalised embryo (like cic^fet-T6/cic^fet-E11 single mutant females) and an eggshell that shows a combination of cic and Egfr mutant phenotypes; the dorsal appendages are broadened (as in cic mutants) but are positioned closer to the dorsal midline (as in Egfr mutants).

(Goff et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

cic^Q677X

(Tseng et al., 2007)

cic^R505W

(Tseng et al., 2007)

cic^Q474X

(Tseng et al., 2007)

cic^Q219X

(Tseng et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant suppressor of the sterility of spz^D1/+ females.

(Goff et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

cic^fet-E11

cic^fetE11

(Papagianni et al., 2018, Jin et al., 2015, Andreu et al., 2012, Ajuria et al., 2011, Astigarraga et al., 2007, Tseng et al., 2007, Atkey et al., 2006)

fet^E11

(Goff et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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