FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\APP-BP1Ex62
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General Information
Symbol
Dmel\APP-BP1Ex62
Species
D. melanogaster
Name
FlyBase ID
FBal0220535
Feature type
allele
Associated gene
Dmel\APP-BP1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kim et al., 2007)
Mutagen
P-element activity
(Kim et al., 2007)
Progenitor genotype
P{lacZ}APP-BP1LP67
(Kim et al., 2007)
Cytology
Description

APP-BP1Ex62 has a 2789bp deletion including 31bp of the fourth exon and the deleted region is from 11090085 to 11092873.

(Kim, 2012.1.10)

Imprecise excision of the progenitor insertion, resulting in a deletion of 2789bp, including the first 3 exons and 31bp of the fourth exon of APP-BP1.

(Kim et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:11,096,985..11,099,773 [+]
Comment:

A 2789 bp deletion resulting from the imprecise excision of P{lacZ}APP-BP1LP67. The deletion removes the first three exons of APP-BP1 and 31bp of the fourth exon.

(Kim, 2012.1.10, Kim et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Very few homozygous clones are recovered in adult eyes.

      Homozygous and APP-BP1Ex62/Df(3L)lxd6 third instar larvae have unusually small imaginal discs. Homozygous eye discs show high levels of apoptosis.

      Homozygous clones in the wing disc are substantially smaller than their wild-type twin spots and show increased levels of apoptosis compared to control clones.

      Homozygous clones in the eye disc show increased levels of apoptosis compared to control clones.

      (Kim et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62, ApplUAS.cTa, Scer\GAL4ap-md544 has visible phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4ap-md544

      (Kim et al., 2007)
      Enhancer of
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62 is an enhancer of increased cell death phenotype of ApplUAS.cTa, Scer\GAL4ap-md544

      (Kim et al., 2007)

      APP-BP1[+]/APP-BP1Ex62 is an enhancer of increased cell death phenotype of Applsd.UAS, Scer\GAL4Bx-MS1096

      (Kim et al., 2007)

      APP-BP1[+]/APP-BP1Ex62 is an enhancer of increased cell death phenotype of ApplsdΔIC.UAS, Scer\GAL4Bx-MS1096

      (Kim et al., 2007)
      Suppressor of
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62 is a suppressor of visible phenotype of Appld

      (Kim et al., 2007)
      Other
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62, ApplUAS.cTa, Scer\GAL4ap-md544 has visible phenotype

      (Kim et al., 2007)
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62 is an enhancer of wing disc phenotype of Applsd.UAS, Scer\GAL4Bx-MS1096

      (Kim et al., 2007)

      APP-BP1[+]/APP-BP1Ex62 is an enhancer of wing disc phenotype of ApplsdΔIC.UAS, Scer\GAL4Bx-MS1096

      (Kim et al., 2007)
      Suppressor of
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62 is a suppressor of anterior scutellar bristle phenotype of Appld

      (Kim et al., 2007)
      NOT Suppressor of
      Statement
      Reference

      APP-BP1[+]/APP-BP1Ex62 is a non-suppressor of posterior scutellar bristle phenotype of Appld

      (Kim et al., 2007)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The loss of anterior scutellar macrochaetae that is seen in Appld flies is partially suppressed by APP-BP1Ex62/+. The loss of posterior scutellar macrochaetae that is seen in Appld flies is not suppressed by APP-BP1Ex62/+.

      Expression of one copy of ApplScer\UAS.cTa under the control of Scer\GAL4ap-md544 in a APP-BP1Ex62/+ background results in loss of thoracic microchaetae and a reduction in scutellum size. This phenotype is more severe at 29[o]C than at 25[o]C.

      The increased cell death seen in the wing discs of animals expressing Applsd.ΔIC.Scer\UAS under the control of Scer\GAL4Bx-MS1096 is enhanced by APP-BP1Ex62/+.

      (Kim et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of BacA\p35Scer\UAS.cHa suppresses the loss of thoracic microchaetae and reduction in scutellum size that is seen in animals expressing one copy of ApplScer\UAS.cTa under the control of Scer\GAL4ap-md544 in a APP-BP1Ex62/+ background.

      (Kim et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      APP-BP1EX62
      (Chan et al., 2008)
      APP-BP1Ex62
      dAPP-BP1ex62
      (Kim, 2012.1.10)
      dAPP-BP1null
      (Kim et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)