FlyBase Allele Report: Dmel\Rab10[JF02058]

General Information

Symbol

Dmel\Rab10^JF02058

Species

D. melanogaster

Name

FlyBase ID

FBal0220549

Feature type

allele

Associated gene

Dmel\Rab10

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02058}

Also Known As

Rab10 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02058}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02058

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Davis et al., 2024)

ameliorates Parkinson's disease 8

modeled by Hsap\LRRK2^{G2019S.UAS.Tag:FLAG}

(Fellgett et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^19-12

(Wang et al., 2025)

abnormal neuroanatomy | larval stage, with Scer\GAL4^nompC.PP

(Wang et al., 2025)

abnormal wound healing | larval stage, with Scer\GAL4^19-12

(Wang et al., 2025)

abnormal wound healing | larval stage, with Scer\GAL4^nompC.PP

(Wang et al., 2025)

Phenotype Manifest In

axon | larval stage, with Scer\GAL4^19-12

(Wang et al., 2025)

axon | larval stage, with Scer\GAL4^nompC.PP

(Wang et al., 2025)

larval multidendritic class III neuron, with Scer\GAL4^19-12

(Wang et al., 2025)

larval multidendritic class III neuron, with Scer\GAL4^nompC.PP

(Wang et al., 2025)

Detailed Description

Statement

Reference

Animals expressing Rab10^JF02058 under the control of Scer\GAL4^grh.D4 are viable, no obvious defects in larval dorsal trunk elongation and airway morphology are observed and the larvae are of comparable size to age-matched controls.

(Wingen et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rab10^JF02058, Scer\GAL4^nompC.PP has abnormal wound healing | larval stage phenotype, suppressible by mys^UAS.cLa, Scer\GAL4^nompC.PP

(Wang et al., 2025)

Rab10^JF02058, Scer\GAL4^nompC.PP has abnormal neuroanatomy | larval stage phenotype, suppressible by mys^UAS.cLa, Scer\GAL4^nompC.PP

(Wang et al., 2025)

Suppressor of

Statement

Reference

Rab10^JF02058, Scer\GAL4^ppk.PG is a suppressor of abnormal wound healing | larval stage phenotype of Rtca^UAS.cSa, Scer\GAL4^ppk.PG

(Wang et al., 2025)

Rab10^JF02058, Scer\GAL4^ppk.PG is a suppressor of abnormal neuroanatomy | larval stage phenotype of Rtca^UAS.cSa, Scer\GAL4^ppk.PG

(Wang et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Rab10^JF02058, Scer\GAL4^nompC.PP has axon | larval stage phenotype, suppressible by mys^UAS.cLa, Scer\GAL4^nompC.PP

(Wang et al., 2025)

Rab10^JF02058, Scer\GAL4^nompC.PP has larval multidendritic class III neuron phenotype, suppressible by mys^UAS.cLa, Scer\GAL4^nompC.PP

(Wang et al., 2025)

Suppressor of

Statement

Reference

Rab10^JF02058, Scer\GAL4^ppk.PG is a suppressor of larval dorsal multidendritic neuron ddaC phenotype of Rtca^UAS.cSa, Scer\GAL4^ppk.PG

(Wang et al., 2025)

Rab10^JF02058, Scer\GAL4^ppk.PG is a suppressor of axon | larval stage phenotype of Rtca^UAS.cSa, Scer\GAL4^ppk.PG

(Wang et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26289

y¹ v¹; P{TRiP.JF02058}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rab10^JF02058

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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