FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ctr1AdN.UAS.Tag:FLAG
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General Information
Symbol
Dmel\Ctr1AdN.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0221300
Feature type
allele
Associated gene
Dmel\Ctr1A
Associated Insertion(s)
Carried in Construct
P{UAS-Ctr1A.dN.FLAG}
Also Known As
UAS-Ctr1A, UAS-Ctr1AFLAG
Key Links
Transgenic product class
inframe_deletion
(Binks et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Binks et al., 2010)
Mutagen
in vitro construct
(Zhang et al., 2021, Norgate et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Ctr1A.dN.FLAG}
Cytology
Description

UASt regulatory sequences drive expression of an N-terminally truncated version of Ctr1A, which starts at residue M22.

(Binks et al., 2010)

Expression of Ctr1A cDNA (amplified from S2 cell cDNA with primers: F1 5' gaGGTACCatgcaccacgatcacagcg 3' and R1 5'gcTCTAGAgtgacagtgctcggttacg 3'), fused in frame at the c-terminus to the epitope flag Tag:FLAG, is under the control of UASt sequences.

(Norgate et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ctr1A
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Menkes disease
      modeled by slmbGD10682
      (Zhang et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ctr1AScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa has no effect on the eye.

      (Binks et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG rescues the cuticle hypopigmentation phenotype caused by expression of ATP7Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4pnr-MD237.

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG has no effect on the "Minute"-like phenotype caused by expression of ScoxGD898 under the control of Scer\GAL4pnr-MD237.

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG enhances the rough eye phenotype caused by expression of Ctr1BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa.

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG and ATP7GD3322 under the control of Scer\GAL4GMR.PFa results in male lethality, while females have a severe rough eye phenotype.

      (Binks et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Ctr1AdN.UAS.Tag:FLAG/Scer\GAL4pnr-MD237 rescues Ctr1AGD16726

      (Binks et al., 2010)
      Fails to rescue

      Ctr1AdN.UAS.Tag:FLAG/Scer\GAL4GMR.PFa fails to rescue Ctr1AGD16726

      (Binks et al., 2010)
      Comments

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG rescues the cuticle hypopigmentation phenotype caused by expression of a weak Ctr1AGD16726 line under the control of Scer\GAL4pnr-MD237.

      Co-expression of Ctr1AScer\UAS.T:Zzzz\FLAG does not rescue the eye phenotype caused by expression of Ctr1AGD16726 under the control of Scer\GAL4GMR.PFa.

      (Binks et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ctr1AScer\UAS.T:Zzzz\FLAG
      Ctr1AUAS.Tag:FLAG
      Ctr1AdN.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (7)