FlyBase Allele Report: Ecol\lexA[GAD.repo]

General Information

Symbol

Ecol\lexA^GAD.repo

Species

E. coli

Name

FlyBase ID

FBal0221468

Feature type

allele

Associated gene

Ecol\lexA

Associated Insertion(s)

Carried in Construct

P{repo-LexA-GAD}

Also Known As

repo-lexA, Repo-LexA::GAD

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Lai and Lee, 2006)

Progenitor genotype

Carried in construct

P{repo-LexA-GAD}

Cytology

Description

An 8.5kb genomic fragment from immediately upstream of the repo gene regulates expression of a lexA::GAD driver.

(Lai and Lee, 2006)

Allele components

Component

Use(s)

Regulatory region(s)

repo

Encoded product / tool

lexA::GAD

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval glial cell

(Dong et al., 2021)

third instar larval stage

larval glial cell

(Portela et al., 2019)

wandering third instar larval stage

larval glial cell

(Peng et al., 2019)

adult stage

adult glial cell

(Awasaki et al., 2008)

adult CNS glial cell

(Lai and Lee, 2006)

Additional Information

Statement

Reference

Drives expression in glial cells.

(FlyBase Curators, 2017)

EcollexA^GAD.repo drives pan-glial expression.

(Awasaki et al., 2008)

Marker for

Reflects expression of

repo

(Dong et al., 2021, Peng et al., 2019, Portela et al., 2019, Awasaki et al., 2008, Lai and Lee, 2006)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with htl^λ.lexAop

(Dong et al., 2021)

decreased cell number | larval stage, with htl^λ.lexAop

(Dong et al., 2021)

decreased occurrence of cell division | larval stage, with htl^λ.lexAop

(Dong et al., 2021)

Phenotype Manifest In

neuroblast | larval stage, with htl^λ.lexAop

(Dong et al., 2021)

neuron | decreased number | larval stage, with htl^λ.lexAop

(Dong et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

Hsap\TREM2^{R47H.13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

NOT Enhancer of

Statement

Reference

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

NOT Suppressor of

Statement

Reference

htl^λ.lexAop/Ecol\lexA^GAD.repo is a non-suppressor of increased occurrence of cell division | larval stage phenotype of Scer\GAL4^nab, ci^NIG.2125R

(Dong et al., 2021)

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is an enhancer of adult brain | progressive phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

Hsap\TREM2^{R47H.13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is an enhancer of adult brain | progressive phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

NOT Enhancer of

Statement

Reference

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is a non-enhancer of adult brain phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

NOT Suppressor of

Statement

Reference

htl^λ.lexAop/Ecol\lexA^GAD.repo is a non-suppressor of neuroblast | larval stage phenotype of Scer\GAL4^nab, ci^NIG.2125R

(Dong et al., 2021)

Hsap\TREM2^{13xlexAop.Tag:MYC,Tag:FLAG}, Hsap\TYROBP^{13xlexAop.Tag:MYC,Tag:FLAG}, Ecol\lexA^GAD.repo is a non-suppressor of adult brain phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Sekiya et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ecol\lexA^GAD.repo

Ecol\lexA^{repo.T:Scer\GAL4-GAD}

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections