FlyBase Allele Report: Dmel\Glyat[c02982]

General Information

Symbol

Dmel\Glyat^c02982

Species

D. melanogaster

Name

FlyBase ID

FBal0224970

Feature type

allele

Associated gene

Dmel\Glyat

Associated Insertion(s)

PBac{PB}Glyat^c02982

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

PBac{PB}Glyat^c02982

Cytology

Description

A piggyBac insertion into the second exon of Glyat that generates a truncated protein that deletes most of the coding region, including the critical Gcn5-related N-acetyltransferases (GNAT) domain.

(Ren et al., 2017)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:8,010,339..8,010,339 [-]

(Ren et al., 2017, FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by scrib^RNAi.UAS.cUa

(Xu et al., 2022)

modeled by egr^GS9830

(Xu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Ren et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Glyat^c02982 homozygotes are viable and do not exhibit any discernible phenotype, as compared to controls.

(Ren et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Glyat^c02982/Glyat[+] is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

NOT Suppressor of

Statement

Reference

Glyat^c02982/Glyat[+] is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PU, p53^UAS.Ex

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, p53^UAS.Ex

(Ren et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Glyat^c02982/Glyat[+] is a suppressor | partially of anterior crossvein | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of eye disc morphogenetic furrow | third instar larval stage phenotype of Scer\GAL4^GMR.PU, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of anterior crossvein | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^CA.UAS

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of eye disc morphogenetic furrow | third instar larval stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Ren et al., 2017)

Glyat^c02982/Glyat[+] is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, egr^GS9830

(Ren et al., 2017)

NOT Suppressor of

Statement

Reference

Glyat^c02982/Glyat[+] is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, p53^UAS.Ex

(Ren et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Glyat^c02982 partially suppresses both the eye-related phenotypes (i.e. increased apoptosis at the morphogenetic furrow of the third instar larval eye disc and the decreased eye size in adults) and the wing-related phenotypes (i.e. increased apoptosis around the anterior-posterior compartment boundary of the third instar larval wing disc and the highly penetrant anterior crossvein loss in the adult wing) resulting from the expression of egr^GS9830 or hep^CA.Scer\UAS under the control of Scer\GAL4^GMR.PU (eye phenotypes) or Scer\GAL4^ptc-559.1 (wing phenotypes) and partially suppresses the increased apoptosis around the anterior-posterior compartment boundary of the third instar larval wing disc resulting from the expression of either puc^GD1515 or l(2)gl^GD4047 under the control of Scer\GAL4^ptc-559.1, but does not suppress the small eye phenotype resulting from the expression of p53^Scer\UAS.Ex under the control of Scer\GAL4^GMR.PU.

(Ren et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG34010^c02982

Glyat^c02982

dGLYAT^c02982

(Xu et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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